p63 regulates an adhesion programme and cell survival in epithelial cells
- PMID: 16715076
- DOI: 10.1038/ncb1420
p63 regulates an adhesion programme and cell survival in epithelial cells
Abstract
p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates. By characterising transcriptional changes and cellular effects following modulation of p63 expression, we have defined a vital role for p63 in cellular adhesion. Knockdown of p63 expression caused downregulation of cell adhesion-associated genes, cell detachment and anoikis in mammary epithelial cells and keratinocytes. Conversely, overexpression of the TAp63gamma or deltaNp63alpha isoforms of p63 upregulated cell adhesion molecules, increased cellular adhesion and conferred resistance to anoikis. Apoptosis induced by loss of p63 was rescued by signalling downstream of beta4 integrin. Our results implicate p63 as a key regulator of cellular adhesion and survival in basal cells of the mammary gland and other stratified epithelial tissues.
Similar articles
-
ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells.BMC Cancer. 2016 Oct 10;16(1):782. doi: 10.1186/s12885-016-2808-x. BMC Cancer. 2016. PMID: 27724925 Free PMC article.
-
Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling.Cell Death Dis. 2015 Jan 22;6(1):e1619. doi: 10.1038/cddis.2014.583. Cell Death Dis. 2015. PMID: 25611393 Free PMC article.
-
Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.Carcinogenesis. 2006 Jan;27(1):53-63. doi: 10.1093/carcin/bgi200. Epub 2005 Aug 4. Carcinogenesis. 2006. PMID: 16081516
-
[Expression and function of p63 gene in epithelial cells].Izv Akad Nauk Ser Biol. 2007 Jul-Aug;(4):389-93. Izv Akad Nauk Ser Biol. 2007. PMID: 17969255 Review. Russian.
-
p63 and epithelial biology.Exp Cell Res. 2006 Apr 1;312(6):695-706. doi: 10.1016/j.yexcr.2005.11.028. Epub 2006 Jan 9. Exp Cell Res. 2006. PMID: 16406339 Review.
Cited by
-
Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects.Respir Res. 2015 Aug 5;16(1):95. doi: 10.1186/s12931-015-0254-y. Respir Res. 2015. PMID: 26243279 Free PMC article.
-
Epidermal Stem Cells in Homeostasis and Wound Repair of the Skin.Adv Wound Care (New Rochelle). 2013 Jul;2(6):273-282. doi: 10.1089/wound.2012.0372. Adv Wound Care (New Rochelle). 2013. PMID: 24527349 Free PMC article. Review.
-
Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma.Nat Commun. 2014;5:3261. doi: 10.1038/ncomms4261. Nat Commun. 2014. PMID: 24531128 Free PMC article.
-
Control of p53-dependent transcription and enhancer activity by the p53 family member p63.J Biol Chem. 2019 Jul 5;294(27):10720-10736. doi: 10.1074/jbc.RA119.007965. Epub 2019 May 21. J Biol Chem. 2019. PMID: 31113863 Free PMC article.
-
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Cell Death Differ. 2011 Sep;18(9):1487-99. doi: 10.1038/cdd.2011.81. Epub 2011 Jul 15. Cell Death Differ. 2011. PMID: 21760596 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
