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. 2006 Apr;26(2):99-106.
doi: 10.1111/j.1440-1789.2006.00658.x.

Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma

Lei Zhang  1 , Wei-Ping Zhang, Hua Hu, Meng-Ling Wang, Wen-Wen Sheng, Hong-Tian Yao, Wei Ding, Zhong Chen, Er-Qing Wei
Affiliations

Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma

Lei Zhang et al. Neuropathology. 2006 Apr.

Abstract

5-Lipoxygenase (5-LOX) is a key enzyme in the metabolism of arachidonic acid to leukotrienes. The levels of leukotrienes increase after brain injury and when tumors are present. It has been reported that 5-LOX is widely expressed in the brain and that 5-LOX inhibition provides neuroprotection. However, there is still no information available for the expression patterns of 5-LOX in human brain following trauma or with astrocytomas. We investigated its expression patterns by immunohistochemistry. We found that 5-LOX is normally expressed in neurons and glial cells. In neurons, it was expressed in two patterns: in the cytosol and nucleus or only in the cytosol. In traumatic brain injury, 5-LOX expression increased in glial cells and neutrophils. Double-labeling immunohistochemistry showed that part of the 5-LOX-positive glial cells were GFAP positive. No 5-LOX expression was found in brain microvessel endothelia, except in the regenerated endothelia of a patient 8 days following brain trauma. Furthermore, 5-LOX expression increased and showed a granular pattern in high-grade (grade III/IV) astrocytoma. These results indicate that 5-LOX has multiple expression patterns, and can be induced by brain injury, which implies that 5-LOX might have pathophysiological roles in the human brain.

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