The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

doi:10.1186/1471-2334-6-82

. 2006 May 4:6:82.

doi: 10.1186/1471-2334-6-82.

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong¹, W K Eddie Ip, Gloria Hoi Wan Tso, Man Wai Ng, Wilfred Hing Sang Wong, Helen Ka Wai Law, Raymond W H Yung, Eudora Y Chow, K L Au, Eric Y T Chan, Wilina Lim, J S Malik Peiris, Yu Lung Lau

Affiliations

Affiliation

¹ Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. h9820905@graduate.hku.hk

PMID: 16672072
PMCID: PMC1468415
DOI: 10.1186/1471-2334-6-82

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong et al. BMC Infect Dis. 2006.

. 2006 May 4:6:82.

doi: 10.1186/1471-2334-6-82.

Authors

Affiliation

¹ Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. h9820905@graduate.hku.hk

PMID: 16672072
PMCID: PMC1468415
DOI: 10.1186/1471-2334-6-82

Abstract

Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS.

Results: IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility.

Conclusion: IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.

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References

1. Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY, SARS study group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–25. doi: 10.1016/S0140-6736(03)13077-2. - DOI - PMC - PubMed
1. Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med. 2004;10:S88–97. doi: 10.1038/nm1143. - DOI - PMC - PubMed
1. Lau YL, Peiris JM. Pathogenesis of severe acute respiratory syndrome. Curr Opin Immunol. 2005;17:404–10. doi: 10.1016/j.coi.2005.05.009. - DOI - PMC - PubMed
1. Booth CM, Matukas LM, Tomlinson GA, Rachlis AR, Rose DB, Dwosh HA, Walmsley SL, Mazzulli T, Avendano M, Derkach P, Ephtimios IE, Kitai I, Mederski BD, Shadowitz SB, Gold WL, Hawryluck LA, Rea E, Chenkin JS, Cescon DW, Poutanen SM, Detsky AS. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003;289:2801–9. doi: 10.1001/jama.289.21.JOC30885. - DOI - PubMed
1. Chan JW, Ng CK, Chan YH, Mok TY, Lee S, Chu SY, Law WL, Lee MP, Li PC. Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS) Thorax. 2003;58:686–9. doi: 10.1136/thorax.58.8.686. - DOI - PMC - PubMed

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[1] Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY, SARS study group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–25. doi: 10.1016/S0140-6736(03)13077-2. - DOI - PMC - PubMed

[2] Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY, SARS study group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–25. doi: 10.1016/S0140-6736(03)13077-2. - DOI - PMC - PubMed

[3] Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med. 2004;10:S88–97. doi: 10.1038/nm1143. - DOI - PMC - PubMed

[4] Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med. 2004;10:S88–97. doi: 10.1038/nm1143. - DOI - PMC - PubMed

[5] Lau YL, Peiris JM. Pathogenesis of severe acute respiratory syndrome. Curr Opin Immunol. 2005;17:404–10. doi: 10.1016/j.coi.2005.05.009. - DOI - PMC - PubMed

[6] Lau YL, Peiris JM. Pathogenesis of severe acute respiratory syndrome. Curr Opin Immunol. 2005;17:404–10. doi: 10.1016/j.coi.2005.05.009. - DOI - PMC - PubMed

[7] Booth CM, Matukas LM, Tomlinson GA, Rachlis AR, Rose DB, Dwosh HA, Walmsley SL, Mazzulli T, Avendano M, Derkach P, Ephtimios IE, Kitai I, Mederski BD, Shadowitz SB, Gold WL, Hawryluck LA, Rea E, Chenkin JS, Cescon DW, Poutanen SM, Detsky AS. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003;289:2801–9. doi: 10.1001/jama.289.21.JOC30885. - DOI - PubMed

[8] Booth CM, Matukas LM, Tomlinson GA, Rachlis AR, Rose DB, Dwosh HA, Walmsley SL, Mazzulli T, Avendano M, Derkach P, Ephtimios IE, Kitai I, Mederski BD, Shadowitz SB, Gold WL, Hawryluck LA, Rea E, Chenkin JS, Cescon DW, Poutanen SM, Detsky AS. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003;289:2801–9. doi: 10.1001/jama.289.21.JOC30885. - DOI - PubMed

[9] Chan JW, Ng CK, Chan YH, Mok TY, Lee S, Chu SY, Law WL, Lee MP, Li PC. Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS) Thorax. 2003;58:686–9. doi: 10.1136/thorax.58.8.686. - DOI - PMC - PubMed

[10] Chan JW, Ng CK, Chan YH, Mok TY, Lee S, Chu SY, Law WL, Lee MP, Li PC. Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS) Thorax. 2003;58:686–9. doi: 10.1136/thorax.58.8.686. - DOI - PMC - PubMed

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The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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