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. 2006 Apr;1761(4):474-83.
doi: 10.1016/j.bbalip.2006.03.010. Epub 2006 Apr 7.

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Yusuke Ohno  1 , Akio Kihara, Takamitsu Sano, Yasuyuki Igarashi
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Free article

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Yusuke Ohno et al. Biochim Biophys Acta. 2006 Apr.
Free article

Abstract

Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases. Although multiple DHHC proteins are found in eukaryotes, characterization has been examined for only a few. Here, we have cloned all the yeast and human DHHC genes and investigated their intracellular localization and tissue-specific expression. Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole. Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein.

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