doi: 10.1016/j.bmcl.2006.04.011.
Epub 2006 Apr 27.
Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids
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- PMID: 16644213
- DOI: 10.1016/j.bmcl.2006.04.011
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Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids
Bioorg Med Chem Lett.
.
Abstract
A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.
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