Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways
- PMID: 16626391
- DOI: 10.1111/j.1474-9726.2006.00205.x
Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways
Abstract
Molecular genetics in lower organisms has allowed the elucidation of pathways that modulate the aging process. In certain instances, evolutionarily conserved genes and pathways have been shown to regulate lifespan in mammals as well. Many gene products known to affect lifespan are intimately involved in the control of energy metabolism, including the fuel sensor AMP-activated protein kinase (AMPK). We have shown previously that over-expression of an AMPK alpha subunit in Caenorhabditis elegans, designated aak-2, increases lifespan. Here we show the interaction of aak-2 with other pathways known to control aging in worms. Lifespan extension caused by daf-2/insulin-like signaling mutations was highly dependent on aak-2, as was the lifespan extension caused by over-expression of the deacetylase, sir-2.1. Similarly, there was partial requirement for aak-2 in lifespan extension by mitochondrial mutations (isp-1 and clk-1). Conversely, aak-2 was not required for lifespan extension in mutants lacking germline stem cells (glp-1) or mutants of the eating response (eat-2). These results show that aging is controlled by overlapping but distinct pathways and that AMPK/aak-2 represents a node in a network of evolutionarily conserved biochemical pathways that control aging.
Similar articles
-
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.Genes Dev. 2004 Dec 15;18(24):3004-9. doi: 10.1101/gad.1255404. Epub 2004 Dec 1. Genes Dev. 2004. PMID: 15574588 Free PMC article.
-
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.Hum Mol Genet. 2008 Jul 15;17(14):2108-17. doi: 10.1093/hmg/ddn109. Epub 2008 Apr 7. Hum Mol Genet. 2008. PMID: 18397876
-
Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.Biogerontology. 2010 Feb;11(1):31-43. doi: 10.1007/s10522-009-9225-3. Epub 2009 Apr 16. Biogerontology. 2010. PMID: 19370397
-
5'-AMP-activated protein kinase signaling in Caenorhabditis elegans.Exp Biol Med (Maywood). 2008 Jan;233(1):12-20. doi: 10.3181/0705-MR-117. Exp Biol Med (Maywood). 2008. PMID: 18156301 Review.
-
A pathway that links reproductive status to lifespan in Caenorhabditis elegans.Ann N Y Acad Sci. 2010 Aug;1204:156-62. doi: 10.1111/j.1749-6632.2010.05640.x. Ann N Y Acad Sci. 2010. PMID: 20738286 Review.
Cited by
-
Mitochondria and organismal longevity.Curr Genomics. 2012 Nov;13(7):519-32. doi: 10.2174/138920212803251427. Curr Genomics. 2012. PMID: 23633912 Free PMC article.
-
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan.J Mol Med (Berl). 2011 Jul;89(7):667-76. doi: 10.1007/s00109-011-0748-0. Epub 2011 Mar 23. J Mol Med (Berl). 2011. PMID: 21431325 Free PMC article. Review.
-
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration.Biogerontology. 2024 Feb;25(1):83-106. doi: 10.1007/s10522-023-10072-9. Epub 2023 Nov 2. Biogerontology. 2024. PMID: 37917219 Free PMC article. Review.
-
Lipid and glucose metabolism in senescence.Front Nutr. 2023 Aug 23;10:1157352. doi: 10.3389/fnut.2023.1157352. eCollection 2023. Front Nutr. 2023. PMID: 37680899 Free PMC article. Review.
-
AMPK at the nexus of energetics and aging.Cell Metab. 2014 Jul 1;20(1):10-25. doi: 10.1016/j.cmet.2014.03.002. Epub 2014 Apr 10. Cell Metab. 2014. PMID: 24726383 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
