The pathways of oxygen in brain. I. Delivery and metabolism of oxygen
- PMID: 16594162
- DOI: 10.1007/0-387-26206-7_36
The pathways of oxygen in brain. I. Delivery and metabolism of oxygen
Abstract
Flow-metabolism coupling in brain is different from flow-metabolism coupling in other vascular beds. In the classic description of Krogh, the capillary bed is a system of parallel tubes serving cylinders of tissue known as Krogh's cylinders. This simple arrangement yielded a quantitative expression of oxygen delivery to the tissue. However, in brain tissue, the arrangement is so disorderly that no prediction of oxygen tensions in the tissue is possible. Only two claims of the capillary bed in the brain appear to be indisputable, i.e., the capillaries have a common arterial source and a common venous terminus, and their density is proportional to the average regional rates of metabolism at steady-state. The following revision of the mechanism of flow-metabolism coupling in brain arose from the simple assumption, first introduced by Erwin R. Weibel in The Pathway for Oxygen, that every segment of the capillary bed "feeds" the same amount of brain tissue, i.e., that every fraction of the tissue is served by commensurate fractions of capillary density and oxygen diffusibility and accounts for the same fraction of the total oxygen consumption.
Similar articles
-
Cerebral blood flow regulation in REM sleep: a model for flow-metabolism coupling.Arch Ital Biol. 1999 May;137(2-3):165-79. Arch Ital Biol. 1999. PMID: 10349495 Review.
-
Krogh's capillary recruitment hypothesis, 100 years on: Is the opening of previously closed capillaries necessary to ensure muscle oxygenation during exercise?Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H425-H447. doi: 10.1152/ajpheart.00384.2019. Epub 2019 Dec 13. Am J Physiol Heart Circ Physiol. 2020. PMID: 31834819
-
A stochastic model for the transport of oxygen to brain tissue.Adv Exp Med Biol. 1976;75:267-77. doi: 10.1007/978-1-4684-3273-2_33. Adv Exp Med Biol. 1976. PMID: 1015411
-
The effects of capillary transit time heterogeneity (CTH) on brain oxygenation.J Cereb Blood Flow Metab. 2015 May;35(5):806-17. doi: 10.1038/jcbfm.2014.254. Epub 2015 Feb 11. J Cereb Blood Flow Metab. 2015. PMID: 25669911 Free PMC article.
-
Krogh cylinders in retinal development, panretinal hypoperfusion and diabetic retinopathy.Acta Ophthalmol. 2010 Dec;88(8):817-35. doi: 10.1111/j.1755-3768.2009.01796.x. Acta Ophthalmol. 2010. PMID: 20064121 Review.
Cited by
-
Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing.J Neurosci. 2012 Jun 27;32(26):8940-51. doi: 10.1523/JNEUROSCI.0026-12.2012. J Neurosci. 2012. PMID: 22745494 Free PMC article.
-
Resting Rates of Blood Flow and Glucose Use per Neuron Are Proportional to Number of Endothelial Cells Available per Neuron Across Sites in the Rat Brain.Front Integr Neurosci. 2022 Jun 10;16:821850. doi: 10.3389/fnint.2022.821850. eCollection 2022. Front Integr Neurosci. 2022. PMID: 35757100 Free PMC article.
-
Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia.J Physiol. 2016 Sep 15;594(18):5317-28. doi: 10.1113/JP272404. Epub 2016 Jul 9. J Physiol. 2016. PMID: 27256521 Free PMC article.
-
Hyperbaric oxygen therapy in experimental and clinical stroke.Med Gas Res. 2016 Jul 11;6(2):111-118. doi: 10.4103/2045-9912.184721. eCollection 2016 Apr-Jun. Med Gas Res. 2016. PMID: 27867477 Free PMC article. Review.
-
Cerebral Oxygen Delivery and Consumption in Brain-Injured Patients.J Pers Med. 2022 Oct 25;12(11):1763. doi: 10.3390/jpm12111763. J Pers Med. 2022. PMID: 36573716 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
