The antifibrotic effect of TGF-beta1 siRNAs in murine model of liver cirrhosis
- PMID: 16579972
- DOI: 10.1016/j.bbrc.2006.03.087
The antifibrotic effect of TGF-beta1 siRNAs in murine model of liver cirrhosis
Abstract
Liver fibrosis results from chronic damage to the liver by chronic hepatitis, alcohol, and toxic agents. A characteristic of liver fibrosis is an accumulation of extracellular matrix (ECM) protein, which distorts the hepatic architecture by forming a fibrous scar, and the subsequent development of regenerating nodules defines cirrhosis. Transforming growth factor (TGF)-beta1, one of the most powerful profibrogenic mediators, plays a major role in the development of liver cirrhosis and regulates ECM gene expression and matrix degradation. This study elucidates the changes of TGF-beta1-mediated signals during liver fibrogenesis by using RNA interference. In this experiment, the TGF-beta1 siRNAs reduced the expression of TGF-beta1 in the livers of CCl(4) injection compared with those of control group, and the expression of type I collagen and alpha-smooth muscle actin was decreased. In conclusion, this study demonstrates that TGF-beta1 siRNAs inhibit TGF-beta1 expression in the murine model of liver cirrhosis and might be a good therapeutic strategy to prevent liver cirrhosis in human.
Similar articles
-
Effects of RNA interference targeting transforming growth factor-beta 1 on immune hepatic fibrosis induced by Concanavalin A in mice.Hepatobiliary Pancreat Dis Int. 2009 Jun;8(3):300-8. Hepatobiliary Pancreat Dis Int. 2009. PMID: 19502172
-
Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells.J Gastroenterol Hepatol. 2008 Dec;23(12):1917-25. doi: 10.1111/j.1440-1746.2008.05485.x. Epub 2008 Aug 28. J Gastroenterol Hepatol. 2008. PMID: 18761555
-
Adenoviral expression of a transforming growth factor-beta1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats.BMC Gastroenterol. 2003 Oct 18;3:29. doi: 10.1186/1471-230X-3-29. BMC Gastroenterol. 2003. PMID: 14565855 Free PMC article.
-
Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis.Liver Int. 2006 Feb;26(1):8-22. doi: 10.1111/j.1478-3231.2005.01192.x. Liver Int. 2006. PMID: 16420505 Review.
-
[The role of TGFbeta1 and IL-13 in cellular signal transduction of hepatic fibrosis of schistosomiasis].Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009 Aug;27(4):357-60. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009. PMID: 20066997 Review. Chinese.
Cited by
-
Preliminary experimental study of urethral reconstruction with tissue engineering and RNA interference techniques.Asian J Androl. 2013 May;15(3):430-3. doi: 10.1038/aja.2013.2. Epub 2013 Apr 1. Asian J Androl. 2013. PMID: 23542139 Free PMC article.
-
siRNA- and miRNA-based therapeutics for liver fibrosis.Transl Res. 2019 Dec;214:17-29. doi: 10.1016/j.trsl.2019.07.007. Epub 2019 Aug 13. Transl Res. 2019. PMID: 31476281 Free PMC article. Review.
-
Therapeutic Effect of Polymeric Nanomicelles Formulation of LY2157299-Galunisertib on CCl4-Induced Liver Fibrosis in Rats.J Pers Med. 2022 Nov 1;12(11):1812. doi: 10.3390/jpm12111812. J Pers Med. 2022. PMID: 36579532 Free PMC article.
-
Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene.J Gene Med. 2009 Sep;11(9):764-71. doi: 10.1002/jgm.1357. J Gene Med. 2009. PMID: 19554613 Free PMC article.
-
The anti-fibrotic effect of bone morphogenic protein-7(BMP-7) on liver fibrosis.Int J Med Sci. 2013;10(4):441-50. doi: 10.7150/ijms.5765. Epub 2013 Mar 2. Int J Med Sci. 2013. PMID: 23471555 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
