doi: 10.1124/mi.6.2.6.
Iron dysregulation and neurodegeneration: the molecular connection
Affiliations
- PMID: 16565471
- DOI: 10.1124/mi.6.2.6
Item in Clipboard
Iron dysregulation and neurodegeneration: the molecular connection
Mol Interv.
2006 Apr.
Abstract
Iron is essential for many biological processes however excess concentrations can be harmful to many tissues. Its amounts must therefore be carefully regulated in all cells of the body including those in the brain. Increased amounts of iron have been reported in many neurodegenerative disorders. Whether this increased iron contributes to neurodegeneration has been considered controversial. In this review, we discuss some recently identified anomalies in proteins linked with iron metabolism which signify a critical role for iron dysregulation in neurodegeneration.
Similar articles
-
Intestinal absorption of iron in HFE-1 hemochromatosis: local or systemic process?J Hepatol. 2004 Apr;40(4):702-9. doi: 10.1016/j.jhep.2004.01.020. J Hepatol. 2004. PMID: 15030990 Review. No abstract available.
-
Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis.J Cell Physiol. 2005 Aug;204(2):489-99. doi: 10.1002/jcp.20315. J Cell Physiol. 2005. PMID: 15744772
-
[Progress in the study of molecular genetics of iron metabolism].Nihon Naika Gakkai Zasshi. 2000 Apr 10;89(4):768-73. Nihon Naika Gakkai Zasshi. 2000. PMID: 10876938 Review. Japanese. No abstract available.
-
Iron on the brain.Nat Genet. 2001 Aug;28(4):299-300. doi: 10.1038/91036. Nat Genet. 2001. PMID: 11479580
-
Iron metabolism in mammalian cells.Int Rev Cytol. 2001;211:241-78. doi: 10.1016/s0074-7696(01)11020-x. Int Rev Cytol. 2001. PMID: 11597005 Review.
Cited by
-
The pivotal role of astrocytes in the metabolism of iron in the brain.Neurochem Res. 2007 Nov;32(11):1884-90. doi: 10.1007/s11064-007-9375-0. Epub 2007 Jun 6. Neurochem Res. 2007. PMID: 17551833 Review.
-
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis.Cell Chem Biol. 2020 Apr 16;27(4):436-447. doi: 10.1016/j.chembiol.2020.03.011. Epub 2020 Apr 9. Cell Chem Biol. 2020. PMID: 32275864 Free PMC article. Review.
-
Therapies targeting lipid peroxidation in traumatic brain injury.Brain Res. 2016 Jun 1;1640(Pt A):57-76. doi: 10.1016/j.brainres.2016.02.006. Epub 2016 Feb 10. Brain Res. 2016. PMID: 26872597 Free PMC article. Review.
-
Intracellular iron transport and storage: from molecular mechanisms to health implications.Antioxid Redox Signal. 2008 Jun;10(6):997-1030. doi: 10.1089/ars.2007.1893. Antioxid Redox Signal. 2008. PMID: 18327971 Free PMC article. Review.
-
The Aging of Iron Man.Front Aging Neurosci. 2018 Mar 12;10:65. doi: 10.3389/fnagi.2018.00065. eCollection 2018. Front Aging Neurosci. 2018. PMID: 29593525 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Medical