Antinociceptive and behavioral effects of ribavirin in mice
- PMID: 16563475
- DOI: 10.1016/j.pbb.2006.01.010
Antinociceptive and behavioral effects of ribavirin in mice
Abstract
The antinociceptive effect of ribavirin, an antiviral drug, was studied after systemic injection using several pain tests in mice. In the hot-plate test of thermal pain, capsaicin-induced chemogenic pain, formalin test and abdominal stretching assay induced by the i.p. injection of 0.6% acetic acid, ribavirin produced a dose-related reduction in nociceptive responses. The visceral antinociceptive effect of ribavirin was unaffected by co-treatment with yohimbine, atropine or theophylline, but partially reversed by naloxone. Antinociception by ribavirin was augmented by treatment with prazosin, doxazosin, propranolol, guanethidine, glibenclamide, baclofen, indomethacin or cysteamine. Further, the ribavirin induced antinociception was enhanced by D2 receptor antagonists haloperidol, sulpiride, clozapine or domperidone and by the dopamine D2 receptor agonist bromocryptine. Ribavirin did not exhibit depression-like effect, nor it influenced the effect of amitriptyline in the forced swimming test. It did not impair cognitive performance in the Morris water Maze test. The present data demonstrate that ribavirin administered via systemic route possesses visceral and thermal anti-nociceptive properties. The ribavirin analgesic effect was partially reversed by naloxone, an opioid antagonist.
Similar articles
-
Antinociceptive properties of the hydroalcoholic extract and the flavonoid rutin obtained from Polygala paniculata L. in mice.Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):306-15. doi: 10.1111/j.1742-7843.2008.00365.x. Epub 2009 Mar 5. Basic Clin Pharmacol Toxicol. 2009. PMID: 19281602
-
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.Pharmacol Biochem Behav. 2005 Jul;81(3):466-77. doi: 10.1016/j.pbb.2005.04.004. Pharmacol Biochem Behav. 2005. PMID: 15907989
-
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.Pharmacol Biochem Behav. 2006 Jan;83(1):90-9. doi: 10.1016/j.pbb.2005.12.010. Epub 2006 Feb 3. Pharmacol Biochem Behav. 2006. PMID: 16458954
-
Antinociceptive effect of leaf essential oil from Croton sonderianus in mice.Life Sci. 2005 Oct 21;77(23):2953-63. doi: 10.1016/j.lfs.2005.05.032. Life Sci. 2005. PMID: 15979097
-
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.Pharmacology. 2005 Nov;75(3):122-32. doi: 10.1159/000088211. Epub 2005 Sep 9. Pharmacology. 2005. PMID: 16155371
Cited by
-
The emergence of obsessive compulsive and compulsive buying symptomatology after acute stress and short-term use of ribavirin: case reports.Ther Adv Psychopharmacol. 2013 Aug;3(4):246-50. doi: 10.1177/2045125312467346. Ther Adv Psychopharmacol. 2013. PMID: 24167697 Free PMC article. No abstract available.
-
Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.Eur J Pharmacol. 2014 Aug 5;736:124-30. doi: 10.1016/j.ejphar.2014.04.041. Epub 2014 May 8. Eur J Pharmacol. 2014. PMID: 24815322 Free PMC article.
-
Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms.Korean J Pain. 2023 Jul 1;36(3):281-298. doi: 10.3344/kjp.23129. Korean J Pain. 2023. PMID: 37394272 Free PMC article. Review.
-
Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder.Curr Pharm Des. 2020;26(4):466-484. doi: 10.2174/1381612826666200115094642. Curr Pharm Des. 2020. PMID: 31939725 Free PMC article. Review.
-
Endogenous opiates and behavior: 2006.Peptides. 2007 Dec;28(12):2435-513. doi: 10.1016/j.peptides.2007.09.002. Epub 2007 Sep 11. Peptides. 2007. PMID: 17949854 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
