Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Oct;10(10):2867-78.
doi: 10.1002/j.1460-2075.1991.tb07836.x.

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor

L Naldini  1 , K M Weidner, E Vigna, G Gaudino, A Bardelli, C Ponzetto, R P Narsimhan, G Hartmann, R Zarnegar, G K Michalopoulos, et al.
Affiliations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor

L Naldini et al. EMBO J. 1991 Oct.

Abstract

Scatter Factor (SF) is a fibroblast-secreted protein which promotes motility and matrix invasion of epithelial cells. Hepatocyte Growth Factor (HGF) is a powerful mitogen for hepatocytes and other epithelial tissues. SF and HGF, purified according to their respective biological activities, were interchangeable and equally effective in assays for cell growth, motility and invasion. Both bound with identical affinities to the same sites in target cells. The receptor for SF and HGF was identified as the product of the MET oncogene by: (i) ligand binding and coprecipitation in immunocomplexes; (ii) chemical crosslinking to the Met beta subunit; (iii) transfer of binding activity in insect cells by a baculovirus carrying the MET cDNA; (iv) ligand-induced tyrosine phosphorylation of the Met beta subunit. SF and HGF cDNA clones from human fibroblasts, placenta and liver had virtually identical sequences. We conclude that the same molecule (SF/HGF) acts as a growth or motility factor through a single receptor in different target cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Oncogene. 1991 Apr;6(4):553-9 - PubMed
    1. Nature. 1989 Nov 23;342(6248):440-3 - PubMed
    1. Cell. 1991 Apr 5;65(1):189-97 - PubMed
    1. Mol Cell Biol. 1991 Jun;11(6):2962-70 - PubMed
    1. Cell Growth Differ. 1990 Feb;1(2):87-95 - PubMed

Publication types

MeSH terms