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Review
. 2006 Mar 13;172(6):803-8.
doi: 10.1083/jcb.200512082. Epub 2006 Mar 6.

RNA granules

Paul Anderson  1 , Nancy Kedersha
Affiliations
Review

RNA granules

Paul Anderson et al. J Cell Biol. .

Abstract

Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold proteins, and RNA-binding proteins, and they control the localization, stability, and translation of their RNA cargo. We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay.

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Figures

Figure 1.
Figure 1.
Comparative composition of cytoplasmic RNA granules. Green, present; red, absent. *, weakly present.
See this image and copyright information in PMC

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References

    1. Amiri, A., B.D. Keiper, I. Kawasaki, Y. Fan, Y. Kohara, R.E. Rhoads, and S. Strome. 2001. An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans. Development. 128:3899–3912. - PMC - PubMed
    1. Anderson, P., and N. Kedersha. 2002. Stressful initiations. J. Cell Sci. 115:3227–3234. - PubMed
    1. Atlas, R., L. Behar, E. Elliott, and I. Ginzburg. 2004. The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells. J. Neurochem. 89:613–626. - PubMed
    1. Audhya, A., F. Hyndman, I.X. McLeod, A.S. Maddox, J.R. Yates III, A. Desai, and K. Oegema. 2005. A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J. Cell Biol. 171:267–279. - PMC - PubMed
    1. Bashkirov, V.I., H. Scherthan, J.A. Solinger, J.M. Buerstedde, and W.D. Heyer. 1997. A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J. Cell Biol. 136:761–773. - PMC - PubMed

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