doi: 10.1038/nsmb1066.
Epub 2006 Mar 5.
Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA
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- PMID: 16518398
- DOI: 10.1038/nsmb1066
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Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA
Nat Struct Mol Biol.
2006 Apr.
Abstract
The highly conserved ribonuclease RNase Z catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Here we present the structure of the complex between Bacillus subtilis RNase Z and tRNA(Thr), the first structure of a ribonucleolytic processing enzyme bound to tRNA. Binding of tRNA to RNase Z causes conformational changes in both partners to promote reorganization of the catalytic site and tRNA cleavage.
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