doi: 10.1016/j.tcb.2006.02.002.
Epub 2006 Mar 3.
Complexity of the TOR signaling network
Affiliations
- PMID: 16516475
- DOI: 10.1016/j.tcb.2006.02.002
Item in Clipboard
Complexity of the TOR signaling network
Trends Cell Biol.
2006 Apr.
Abstract
The target of rapamycin (TOR) is a serine/threonine kinase of the phosphatidylinositol kinase-related kinase family and is highly conserved from yeast to mammals. TOR functions as a central regulator of cell growth and is itself regulated by a wide range of signals, including growth factors, nutrients and stress conditions. Recent studies in eukaryotic cells have identified two distinct TOR complexes, TORC1 and TORC2, which phosphorylate different substrates and have distinct physiological functions. Here, we discuss new findings that have extended the complexity of TOR signaling and the different roles of the TORC complexes in yeast, flies and mammals.
Similar articles
-
The expanding TOR signaling network.Curr Opin Cell Biol. 2005 Apr;17(2):158-66. doi: 10.1016/j.ceb.2005.02.008. Curr Opin Cell Biol. 2005. PMID: 15780592 Review.
-
The TOR signalling network from yeast to man.Int J Biochem Cell Biol. 2006;38(9):1476-81. doi: 10.1016/j.biocel.2006.02.013. Epub 2006 Mar 9. Int J Biochem Cell Biol. 2006. PMID: 16647875 Review.
-
TOR signaling in invertebrates.Curr Opin Cell Biol. 2009 Dec;21(6):825-36. doi: 10.1016/j.ceb.2009.08.007. Epub 2009 Sep 19. Curr Opin Cell Biol. 2009. PMID: 19767189
-
Structure of TOR and its complex with KOG1.Mol Cell. 2007 Aug 3;27(3):509-16. doi: 10.1016/j.molcel.2007.05.040. Mol Cell. 2007. PMID: 17679098
-
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.Oncogene. 2006 Oct 16;25(48):6361-72. doi: 10.1038/sj.onc.1209882. Oncogene. 2006. PMID: 17041622 Review.
Cited by
-
NCI's provocative questions on cancer: some answers to ignite discussion.Oncotarget. 2011 Dec;2(12):1352-67. doi: 10.18632/oncotarget.432. Oncotarget. 2011. PMID: 22267462 Free PMC article.
-
Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.J Clin Invest. 2010 Nov;120(11):4091-101. doi: 10.1172/JCI43873. Epub 2010 Oct 25. J Clin Invest. 2010. PMID: 20972332 Free PMC article.
-
Translational up-regulation and high-level protein expression from plasmid vectors by mTOR activation via different pathways in PC3 and 293T cells.PLoS One. 2010 Dec 28;5(12):e14408. doi: 10.1371/journal.pone.0014408. PLoS One. 2010. PMID: 21203441 Free PMC article.
-
Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes.Endocrinology. 2011 Jan;152(1):151-63. doi: 10.1210/en.2010-0248. Epub 2010 Nov 24. Endocrinology. 2011. PMID: 21106878 Free PMC article.
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.J Exp Med. 2008 Sep 29;205(10):2397-408. doi: 10.1084/jem.20081297. Epub 2008 Sep 22. J Exp Med. 2008. PMID: 18809716 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
