Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jan 8;245(1-2):331-6.
doi: 10.1016/j.canlet.2006.01.014. Epub 2006 Feb 28.

Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11

Marc Schmitz  1 , Rebekka Wehner, Stefan Stevanovic, Andrea Kiessling, Michael A Rieger, Achim Temme, Michael Bachmann, E Peter Rieber, Bernd Weigle
Affiliations

Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11

Marc Schmitz et al. Cancer Lett. .

Abstract

The development of T cell-based immunotherapies of cancer depends on the identification of tumor-associated antigens capable of eliciting tumor-directed cytotoxic T cell responses. In malignant glioma the number of well-defined target antigens for cytotoxic T lymphocytes (CTLs) is still very limited. Recently, we demonstrated the abundant and specific overexpression of the transcription factor SOX11 in malignant glioma. Here, we describe the SOX11-derived peptide LLRRYNVAKV which is capable of inducing human leukocyte antigen-A*0201-restricted and tumor-reactive CTLs. This novel CTL epitope may serve as an attractive candidate for a T cell-based immunotherapy of glioma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources