Review
doi: 10.1016/j.gde.2006.02.007.
Epub 2006 Feb 28.
A question of timing: emerging links between transcription and replication
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- PMID: 16503127
- DOI: 10.1016/j.gde.2006.02.007
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Review
A question of timing: emerging links between transcription and replication
Curr Opin Genet Dev.
2006 Apr.
Abstract
The coordination of transcription and timing of DNA replication during the S phase of the cell cycle has recently been studied chromosome-wide in high resolution. This revealed that in the complex genome of higher eukaryotes actively transcribed genes are more likely to replicate early in S phase. Dynamic changes in chromatin structure and nuclear organization appear to provide the underlying mechanism to link transcription and replication. A possible evolutionary benefit for this connection might result from differential replication fidelity during S phase, and comparisons of the human and chimpanzee genomes are compatible with this hypothesis.
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