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. 2006 Mar 20;580(7):1702-8.
doi: 10.1016/j.febslet.2006.02.017. Epub 2006 Feb 17.

Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter

Da-ming Gao  1 , Lin-fang Wang, Jing Liu, Yu-ying Kong, Yuan Wang, You-hua Xie
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Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter

Da-ming Gao et al. FEBS Lett. .
Free article

Abstract

Liver receptor homologue 1 (LRH-1) plays important roles in many physiological processes and embryogenesis. However, little is known about the developmental regulation of lrh-1 expression. We identified a novel transcript of mouse lrh-1 (mlrh-1v2) from embryonic stem (ES) cells. mlrh-1v2 is expressed throughout embryogenesis and in several adult tissues, while the known transcript (mlrh-1v1) appears later during embryogenesis. mlrh-1v2 expression is directed by a new promoter which displays a strong activity in ES cells. The generation of the new transcript is conserved in rats. The identification of novel mlrh-1 variant and promoter is critical for elucidating LRH-1 functions in development and adult tissues.

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