Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Feb;12(2):343-6.
doi: 10.3201/eid1202.050733.

Novel dengue virus type 1 from travelers to Yap State, Micronesia

Yoko Nukui  1 , Shigeru Tajima, Akira Kotaki, Mikako Ito, Tomohiko Takasaki, Kazuhiko Koike, Ichiro Kurane
Affiliations

Novel dengue virus type 1 from travelers to Yap State, Micronesia

Yoko Nukui et al. Emerg Infect Dis. 2006 Feb.

Abstract

Dengue virus type 1 (DENV-1), which was responsible for the dengue fever outbreak in Yap State, Micronesia, in 2004, was isolated from serum samples of 4 dengue patients in Japan. Genome sequencing demonstrated that this virus belonged to genotype IV and had a 29-nucleotide deletion in the 3 noncoding region.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Nucleotide sequence alignment of the variable region in the 3´ noncoding region of dengue virus type 1 strains, including NIID04-27 sequenced in the present study. The Mochizuki strain was used as the consensus sequence, and the sequence of 100 nucleotides immediately downstream of the open reading frame termination codon is shown at the top. Solid dots indicate nucleotides identical to the consensus sequence and hyphens indicate deletions.
Figure 2
Figure 2
Phylogenetic tree based on the full-length genome sequence of 21 available dengue virus (DENV) type 1 strains and DENV-2, -3, and -4. The multiple sequence alignments were obtained with ClustalX, and the tree was constructed by the neighbor-joining method. The percentage of successful bootstrap replicates is indicated at the nodes. The NIID04-27 strain is indicated in boldface. Genotypes I, II, IV, and V correspond to DENV-1 genotypes as defined by Goncalvez et al. (10).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Guzman MG, Kouri G. Dengue: an update. Lancet Infect Dis. 2002;2:33–42. 10.1016/S1473-3099(01)00171-2 - DOI - PubMed
    1. Takahashi M, Yamada K, Sato Y, Ikawa K, Matsumoto Y, Sano T, et al. Detection of dengue virus-infected patients among passengers at the quarantine station of the New Tokyo International Airport. Jpn J Infect Dis. 2002;55:215–6. - PubMed
    1. Chambers TJ, Hahn CS, Galler R, Rice CM. Flavivirus genome organization, expression, and replication. Annu Rev Microbiol. 1990;44:649–88. 10.1146/annurev.mi.44.100190.003245 - DOI - PubMed
    1. Proutski V, Gritsun TS, Gould EA, Holmes EC. Biological consequences of deletions within the 3´-untranslated region of flaviviruses may be due to rearrangements of RNA secondary structure. Virus Res. 1999;64:107–23. 10.1016/S0168-1702(99)00079-9 - DOI - PubMed
    1. Markoff L. 5´-and- 3´-non coding regions in flavivirus RNA. Adv Virus Res. 2003;59:177–228. 10.1016/S0065-3527(03)59006-6 - DOI - PMC - PubMed

Publication types

Associated data