Nomenclature and functions of RNA-directed RNA polymerases
- PMID: 16473542
- DOI: 10.1016/j.tplants.2006.01.003
Nomenclature and functions of RNA-directed RNA polymerases
Abstract
There is little relationship between eukaryotic RNA-directed RNA polymerases (RDRs), viral RNA-dependent RNA polymerases (RdRps) and DNA-dependent RNA polymerases, indicating that RDRs evolved as an independent class of enzymes early in evolution. In fungi, plants and several animal systems, RDRs play a key role in RNA-mediated gene silencing [post-transcriptional gene silencing (PTGS) in plants and RNA interference (RNAi) in non-plants] and are indispensable for heterochromatin formation, at least, in Schizosaccharomyces pombe and plants. Recent findings indicate that PTGS, RNAi and heterochromatin formation not only function as host defence mechanisms against invading nucleic acids but are also involved in natural gene regulation. RDRs are required for these processes, initiating a broad interest in this enzyme class.
Similar articles
-
Use, tolerance and avoidance of amplified RNA silencing by plants.Trends Plant Sci. 2008 Jul;13(7):317-28. doi: 10.1016/j.tplants.2008.05.004. Epub 2008 Jun 17. Trends Plant Sci. 2008. PMID: 18565786 Review.
-
Evolution of the RNA-dependent RNA polymerase (RdRP) genes: duplications and possible losses before and after the divergence of major eukaryotic groups.Gene. 2009 Nov 1;447(1):29-39. doi: 10.1016/j.gene.2009.07.004. Epub 2009 Jul 17. Gene. 2009. PMID: 19616606
-
Genome-wide identification, organization and phylogenetic analysis of Dicer-like, Argonaute and RNA-dependent RNA Polymerase gene families and their expression analysis during reproductive development and stress in rice.BMC Genomics. 2008 Oct 1;9:451. doi: 10.1186/1471-2164-9-451. BMC Genomics. 2008. PMID: 18826656 Free PMC article.
-
RNA-directed RNA polymerase 1 (RdR1) mediates the resistance of Nicotiana attenuata to herbivore attack in nature.Plant J. 2007 Apr;50(1):40-53. doi: 10.1111/j.1365-313X.2007.03030.x. Epub 2007 Mar 5. Plant J. 2007. PMID: 17346266
-
RNA interference and heterochromatin in the fission yeast Schizosaccharomyces pombe.Trends Genet. 2005 Aug;21(8):450-6. doi: 10.1016/j.tig.2005.06.005. Trends Genet. 2005. PMID: 15979194 Review.
Cited by
-
Cy-1, a major QTL for tomato leaf curl New Delhi virus resistance, harbors a gene encoding a DFDGD-Class RNA-dependent RNA polymerase in cucumber (Cucumis sativus).BMC Plant Biol. 2024 Oct 2;24(1):879. doi: 10.1186/s12870-024-05591-7. BMC Plant Biol. 2024. PMID: 39358692 Free PMC article.
-
Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins.Viruses. 2016 Jul 23;8(7):208. doi: 10.3390/v8070208. Viruses. 2016. PMID: 27455310 Free PMC article. Review.
-
Bioinformatics approaches for viral metagenomics in plants using short RNAs: model case of study and application to a Cicer arietinum population.Front Microbiol. 2015 Jan 27;5:790. doi: 10.3389/fmicb.2014.00790. eCollection 2014. Front Microbiol. 2015. PMID: 25674078 Free PMC article.
-
Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV.PLoS One. 2012;7(11):e49254. doi: 10.1371/journal.pone.0049254. Epub 2012 Nov 8. PLoS One. 2012. PMID: 23145135 Free PMC article.
-
RNA Interference: A Natural Immune System of Plants to Counteract Biotic Stressors.Cells. 2019 Jan 10;8(1):38. doi: 10.3390/cells8010038. Cells. 2019. PMID: 30634662 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
