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. 2006 Feb;9(2):121-32.
doi: 10.1016/j.ccr.2006.01.013.

X chromosomal abnormalities in basal-like human breast cancer

Andrea L Richardson  1 , Zhigang C Wang, Arcangela De Nicolo, Xin Lu, Myles Brown, Alexander Miron, Xiaodong Liao, J Dirk Iglehart, David M Livingston, Shridar Ganesan
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Free article

X chromosomal abnormalities in basal-like human breast cancer

Andrea L Richardson et al. Cancer Cell. 2006 Feb.
Free article

Abstract

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.

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