Review
doi: 10.1016/j.canlet.2005.12.032.
Epub 2006 Feb 8.
Sprouty and cancer: the first terms report
Affiliations
- PMID: 16469433
- DOI: 10.1016/j.canlet.2005.12.032
Item in Clipboard
Review
Sprouty and cancer: the first terms report
Cancer Lett.
.
Abstract
The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.
Similar articles
-
Sprouty genes function in suppression of prostate tumorigenesis.Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20023-8. doi: 10.1073/pnas.1217204109. Epub 2012 Nov 13. Proc Natl Acad Sci U S A. 2012. PMID: 23150596 Free PMC article.
-
The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.Cancer Res. 2004 Sep 1;64(17):6127-36. doi: 10.1158/0008-5472.CAN-04-1207. Cancer Res. 2004. PMID: 15342396
-
The Sprouty/Spred family as tumor suppressors: Coming of age.Cancer Sci. 2019 May;110(5):1525-1535. doi: 10.1111/cas.13999. Epub 2019 Apr 23. Cancer Sci. 2019. PMID: 30874331 Free PMC article. Review.
-
The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.Cancer Res. 2004 Jul 15;64(14):4728-35. doi: 10.1158/0008-5472.CAN-03-3759. Cancer Res. 2004. PMID: 15256439
-
The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis.Int J Mol Sci. 2016 Jan 21;17(1):138. doi: 10.3390/ijms17010138. Int J Mol Sci. 2016. PMID: 26805820 Free PMC article. Review.
Cited by
-
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.J Hepatol. 2012 Sep;57(3):577-83. doi: 10.1016/j.jhep.2012.04.026. Epub 2012 May 19. J Hepatol. 2012. PMID: 22617155 Free PMC article.
-
Sprouty genes function in suppression of prostate tumorigenesis.Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20023-8. doi: 10.1073/pnas.1217204109. Epub 2012 Nov 13. Proc Natl Acad Sci U S A. 2012. PMID: 23150596 Free PMC article.
-
Mammalian tumor-like organs. 2. Mammalian adipose has many tumor features and obesity is a tumor-like process.Infect Agent Cancer. 2022 Apr 8;17(1):15. doi: 10.1186/s13027-022-00423-5. Infect Agent Cancer. 2022. PMID: 35395810 Free PMC article. Review.
-
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.Cancer Cell. 2010 Sep 14;18(3):282-93. doi: 10.1016/j.ccr.2010.08.013. Cancer Cell. 2010. PMID: 20832755 Free PMC article.
-
Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.Breast Cancer Res. 2023 Jul 28;25(1):90. doi: 10.1186/s13058-023-01683-8. Breast Cancer Res. 2023. PMID: 37507768 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Miscellaneous
