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. 2006 Feb 1;66(3):1261-4.
doi: 10.1158/0008-5472.CAN-05-2856.

The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma

Lisette Bevaart  1 , Marco J H Jansen, Martine J van Vugt, J Sjef Verbeek, Jan G J van de Winkel, Jeanette H W Leusen
Affiliations

The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma

Lisette Bevaart et al. Cancer Res. .

Abstract

We examined the role of FcgammaR in antibody therapy of metastatic melanoma in wild-type and different FcgammaR knock-out mice. Treatment of B16F10-challenged wild-type mice with TA99 antibody specific for the gp75 tumor antigen resulted in a marked decrease in numbers of lung metastases. Treatment of individual FcgammaR knock-out mice revealed the high-affinity IgG receptor, FcgammaRI (CD64), to represent the central FcgammaR for TA99-induced antitumor effects. The potential of immune-modulating agents to further enhance the protective effect induced by monoclonal antibody (mAb) TA99 was examined in combination treatments consisting of mAb TA99 and a TLR-4 agonist, monophosphoryl lipid A (MPL). MPL did potently boost TA99 antibody-induced effects, and combination therapy was, again, found to be dependent on the presence of FcgammaRI.

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