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. 2006 Feb;84(1):110-5.
doi: 10.1111/j.1600-0420.2005.00551.x.

Monoamine receptors in human corneal epithelium and endothelium

Matthias Grueb  1 , Barbara Wallenfels-Thilo, Oliver Denk, Joerg Mielke, Eva Reinthal, Jens Martin Rohrbach, Karl Ulrich Bartz-Schmidt
Affiliations
Free article

Monoamine receptors in human corneal epithelium and endothelium

Matthias Grueb et al. Acta Ophthalmol Scand. 2006 Feb.
Free article

Abstract

Purpose: Monoamine receptors are found throughout the body. Reports about the presence of monoamine receptors in the human cornea are inconsistent.

Methods: Immunohistochemistry, immunofluorescence and immunoblotting were used to localize monoamine receptor sites on human corneal epithelium and endothelium.

Results: Antibodies to alpha-1, beta-1 and beta-2 adrenergic receptors and to D1-like and 5HT-7 receptors were bound in corneal epithelium. Antibodies to alpha-1, alpha-2A, beta-1 and beta-2 adrenergic receptors and to 5HT-7 receptors were bound in corneal endothelium.

Conclusions: Our data demonstrate the presence of several monoamine receptors in the human cornea. These receptors may play a role in the regulation of fluid transport or corneal homeostasis.

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