Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses
- PMID: 16422392
- DOI: 10.1080/10408440591034502
Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses
Abstract
This article assesses the nature of the dose-response relationship of human tumor cell lines with a wide range of agents including antineoplastics, toxic substances (i.e., environmental pollutants), nonneoplastic drugs, endogenous agonists, and phyto-compounds. Hormetic-like biphasic dose responses were commonly reported and demonstrated in 136 tumor cell lines from over 30 tissue types for over 120 different agents. Quantitative features of these hormetic dose responses were similar, regardless of tumor cell line or agent tested. That is, the magnitude of the responses was generally modest, with maximum stimulatory responses typically not greater than twice the control, while the width of the stimulatory concentration range was usually less than 100-fold. Particular attention was directed to possible molecular mechanisms of the biphasic nature of the dose response, as well as clinical implications in which a low concentration of chemotherapeutic agent may stimulate tumor cell proliferation. Finally, these findings further support the conclusion that hormetic dose responses are broadly generalizable, being independent of biological model, endpoint measured, and stressor agent, and represent a basic feature of biological responsiveness to chemical and physical stressors.
Comment in
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Cancer biology and hormesis: comments on Calabrese (2005).Crit Rev Toxicol. 2005 Jul;35(6):583-6. doi: 10.1080/10408440500246777. Crit Rev Toxicol. 2005. PMID: 16422393 Review.
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Hormetic effects of hormones, antihormones, and antidepressants on cancer cell growth in culture: in vivo correlates.Crit Rev Toxicol. 2005 Jul;35(6):587-92. doi: 10.1080/10408440500246801. Crit Rev Toxicol. 2005. PMID: 16422394 Review.
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Cancer biology and hormesis: commentary.Crit Rev Toxicol. 2005 Jul;35(6):593-4. doi: 10.1080/10408440500246827. Crit Rev Toxicol. 2005. PMID: 16422395 Review.
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Commentary on "Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses" by Edward J. Calabrese.Crit Rev Toxicol. 2005 Jul;35(6):599-601. doi: 10.1080/10408440500246868. Crit Rev Toxicol. 2005. PMID: 16422397 Review. No abstract available.
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The definition of hormesis and its implications for in vitro to in vivo extrapolation and risk assessment.Crit Rev Toxicol. 2005 Jul;35(6):603-7. doi: 10.1080/10408440500246876. Crit Rev Toxicol. 2005. PMID: 16422398 Review.
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