Review
doi: 10.1038/nrm1834.
MAPKAP kinases - MKs - two's company, three's a crowd
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- PMID: 16421520
- DOI: 10.1038/nrm1834
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Review
MAPKAP kinases - MKs - two's company, three's a crowd
Nat Rev Mol Cell Biol.
2006 Feb.
Abstract
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.
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