Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes
- PMID: 16406167
- DOI: 10.1016/j.virusres.2005.11.020
Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes
Abstract
Latent Epstein-Barr virus (EBV) nuclear antigens (EBNA)-3A, -3B, and -3C are involved in transcription regulation of both viral and cellular genes. In the present study, we chose functionally important regions within EBNA3A, -3B, and -3C genes with putative tumorigenic potential to investigate natural sequence variations among EBV Type I strains circulating in Europe. Based on the identification of linked EBNA3A, -3B, and -3C sequence patterns, we defined five EBNA3 variants in addition to the B95.8 prototype sequence. Phylogenetic analysis revealed that EBNA3 variant 5, the most diverged from the B95.8 sequence, showed an evolutionary history of intertypic recombination events occurring upstream and downstream of the C-terminus of EBNA3A. The frequency of occurrence of the five newly defined EBNA3 variants was similar for strains causing EBV primary infection or reactivation and was also similar within two of the European areas investigated. In addition, preferential linkages of certain EBNA3 variants to distinct latent membrane protein 1 (LMP1) groups were found to exist. Thus, a combination of more than one polymorphic site in the EBV genome might be involved in determining disease characteristics.
Similar articles
-
Epstein-Barr virus latent gene sequences as geographical markers of viral origin: unique EBNA3 gene signatures identify Japanese viruses as distinct members of the Asian virus family.J Gen Virol. 2011 May;92(Pt 5):1032-1043. doi: 10.1099/vir.0.030023-0. Epub 2011 Jan 19. J Gen Virol. 2011. PMID: 21248177
-
Epstein-barr virus (EBV) in healthy carriers: Distribution of genotypes and 30 bp deletion in latent membrane protein-1 (LMP-1) oncogene.J Med Virol. 2004 Aug;73(4):583-8. doi: 10.1002/jmv.20129. J Med Virol. 2004. PMID: 15221903
-
Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity.J Clin Virol. 2006 Jun;36(2):119-25. doi: 10.1016/j.jcv.2006.01.018. Epub 2006 Apr 17. J Clin Virol. 2006. PMID: 16616610
-
Are particular Epstein-Barr virus strains linked to disease?Semin Cancer Biol. 1996 Aug;7(4):209-15. doi: 10.1006/scbi.1996.0028. Semin Cancer Biol. 1996. PMID: 8946605 Review.
-
Regulation and dysregulation of Epstein-Barr virus latency: implications for the development of autoimmune diseases.Autoimmunity. 2008 May;41(4):298-328. doi: 10.1080/08916930802024772. Autoimmunity. 2008. PMID: 18432410 Review.
Cited by
-
Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.PLoS One. 2017 Jun 12;12(6):e0179124. doi: 10.1371/journal.pone.0179124. eCollection 2017. PLoS One. 2017. PMID: 28604802 Free PMC article.
-
Genotypes Distribution of Epstein-Barr Virus among Lymphoma Patients in Ethiopia.Int J Mol Sci. 2023 Sep 9;24(18):13891. doi: 10.3390/ijms241813891. Int J Mol Sci. 2023. PMID: 37762195 Free PMC article.
-
Epstein-Barr virus genetic variation in lymphoblastoid cell lines derived from Kenyan pediatric population.PLoS One. 2015 May 1;10(5):e0125420. doi: 10.1371/journal.pone.0125420. eCollection 2015. PLoS One. 2015. PMID: 25933165 Free PMC article.
-
Genome-wide analysis of wild-type Epstein-Barr virus genomes derived from healthy individuals of the 1,000 Genomes Project.Genome Biol Evol. 2014 Apr;6(4):846-60. doi: 10.1093/gbe/evu054. Genome Biol Evol. 2014. PMID: 24682154 Free PMC article.
-
EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.J Clin Invest. 2012 Apr;122(4):1487-502. doi: 10.1172/JCI58092. Epub 2012 Mar 12. J Clin Invest. 2012. PMID: 22406538 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
