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. 2005 Oct;15(4):281-6.
doi: 10.1111/j.1750-3639.2005.tb00112.x.

Angiocentric neuroepithelial tumor (ANET): a new epilepsy-related clinicopathological entity with distinctive MRI

Arielle Lellouch-Tubiana  1 , Nathalie Boddaert, Marie Bourgeois, Martine Fohlen, Anne Jouvet, Olivier Delalande, David Seidenwurm, Françis Brunelle, Christian Sainte-Rose
Affiliations

Angiocentric neuroepithelial tumor (ANET): a new epilepsy-related clinicopathological entity with distinctive MRI

Arielle Lellouch-Tubiana et al. Brain Pathol. 2005 Oct.

Abstract

Several types of glioneuronal tumors are known to induce intractable partial seizures in children and adults. The most frequent are dysembryoplastic neuroepithelial tumors (DNETs) and gangliogliomas. We report here a new clinicopathological entity within the spectrum of glioneuronal tumors observed in 10 children who underwent surgery for refractory epilepsy. These tumors demonstrate a unique, pathognomonic histological pattern and a specific appearance at magnetic resonance imaging (MRI). The most striking neuropathological feature is an angiocentric polarity of the tumor with gliofibrillary acidic protein (GFAP) positive fusiform and bipolar astrocytic cells arranged around blood vessels (perivascular cuffing with tumoral astrocytes). Characteristic MRI findings include involvement of cortical gray and white matter, intrinsically high signal on T1-weighted images, as well as a stalk like extension to the ventricle. Immunohistochemical neuronal markers (neurofilament protein, synaptophysin and chromogranin) confirm the presence of a neuronal cell component. Therefore, the term angiocentric neuroepithelial tumor (ANET) is proposed.

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References

    1. Ahboucha S, Laalaoui A, Er‐Bazes M, Montange M, Cooper HM, Gamrani H (2003) Differential patterns of glial fibrillary acidic protein‐immunolabeling in the brain of adult lizards. J Comp Neurol 464: 159–171. - PubMed
    1. Alvarez‐Buylla A, Garcia‐Verdugo JM, Tramontin AD (2001) A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci 2:287–293. - PubMed
    1. Aronica E, Leenstra S, van Veelen CW, van Rijen PC, Hulsebos TJ, Tersmette AC, Yankaya B, Troost D (2001) Glioneuronal tumors and medically intractable epilepsy: a clinical study with long‐term follow‐up of seizure outcome after surgery. Epilepsy Res 43: 179–191. - PubMed
    1. Barkovich AJ, Kuzniecky RI, Dobyns WB, Jackson GD, Becker LE, and Evrard P (1996) A classification scheme for malformations of cortical development. Neuropediatrics 27:59–63. - PubMed
    1. Daumas‐Duport C, Scheithauer BW, Chodkiewicz JP, Laws ER, Jr , Vedrenne C (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty‐nine cases. Neurosurgery 23:545–556. - PubMed