Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity
- PMID: 16360119
- DOI: 10.1016/j.bbrc.2005.11.177
Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity
Abstract
Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that rosiglitazone may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson's disease.
Similar articles
-
Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity.Biochem Pharmacol. 2006 Aug 28;72(5):616-23. doi: 10.1016/j.bcp.2006.05.013. Epub 2006 Jun 30. Biochem Pharmacol. 2006. PMID: 16814256
-
Rosiglitazone protects human neuroblastoma SH-SY5Y cells against MPP+ induced cytotoxicity via inhibition of mitochondrial dysfunction and ROS production.J Neurol Sci. 2007 Feb 15;253(1-2):53-60. doi: 10.1016/j.jns.2006.11.020. Epub 2007 Jan 30. J Neurol Sci. 2007. PMID: 17266988
-
Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.Biochem Biophys Res Commun. 2006 May 5;343(2):564-70. doi: 10.1016/j.bbrc.2006.02.186. Epub 2006 Mar 10. Biochem Biophys Res Commun. 2006. PMID: 16554029
-
Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.Neurosci Res. 2005 Feb;51(2):129-38. doi: 10.1016/j.neures.2004.10.001. Neurosci Res. 2005. PMID: 15681030
-
Acetaldehyde.J Appl Toxicol. 1991 Oct;11(5):373-6. doi: 10.1002/jat.2550110513. J Appl Toxicol. 1991. PMID: 1783742 Review. No abstract available.
Cited by
-
Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson's Disease.ACS Omega. 2023 Feb 10;8(7):6825-6837. doi: 10.1021/acsomega.2c07521. eCollection 2023 Feb 21. ACS Omega. 2023. PMID: 36844520 Free PMC article.
-
PPARγ and Cognitive Performance.Int J Mol Sci. 2019 Oct 12;20(20):5068. doi: 10.3390/ijms20205068. Int J Mol Sci. 2019. PMID: 31614739 Free PMC article. Review.
-
Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets.Pharmaceuticals (Basel). 2009 Dec 23;2(3):250-286. doi: 10.3390/ph2030250. Pharmaceuticals (Basel). 2009. PMID: 27713238 Free PMC article. Review.
-
Targetable Pathways for Alleviating Mitochondrial Dysfunction in Neurodegeneration of Metabolic and Non-Metabolic Diseases.Int J Mol Sci. 2021 Oct 23;22(21):11444. doi: 10.3390/ijms222111444. Int J Mol Sci. 2021. PMID: 34768878 Free PMC article. Review.
-
PPARgamma in Neuroblastoma.PPAR Res. 2008;2008:917815. doi: 10.1155/2008/917815. PPAR Res. 2008. PMID: 18528516 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
