Review
doi: 10.1038/nrm1765.
Arp2/3 and SCAR: plants move to the fore
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- PMID: 16341081
- DOI: 10.1038/nrm1765
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Review
Arp2/3 and SCAR: plants move to the fore
Nat Rev Mol Cell Biol.
2005 Dec.
Abstract
The actin-nucleating Arp2/3 complex is essential for life in yeast and animals, but not in plants, in which mutants of Arp2/3 complex components show relatively minor developmental abnormalities. Animal cells control the activity of the Arp2/3 complex through the suppressor of cyclic AMP receptor (SCAR) complex to achieve cell motility. Amazingly, plants have also retained the SCAR cell-motility pathway, and now provide a unique model for the study of new aspects of SCAR function in the absence of cell motility.
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