Review
doi: 10.1016/j.coi.2005.11.003.
Epub 2005 Dec 2.
Priming of T cells by exogenous antigen cross-presented on MHC class I molecules
Affiliations
- PMID: 16326087
- DOI: 10.1016/j.coi.2005.11.003
Item in Clipboard
Review
Priming of T cells by exogenous antigen cross-presented on MHC class I molecules
Curr Opin Immunol.
2006 Feb.
Abstract
Cross-presentation is the process whereby bone-marrow-derived antigen-presenting cells acquire, process and present exogenous antigen as peptides bound to MHC class I molecules to CD8(+) T cells. Professional antigen-presenting cells acquire cell-associated antigen predominantly in the form of protein, then process and present antigenic peptides on their surface MHC class I molecules via several mechanisms and efficiently cross-prime naïve CD8(+) T cells in vivo. This pathway is of considerable interest because it has an important role in the immune surveillance of tissues for pathogens and cancers.
Similar articles
-
Cross-presentation: underlying mechanisms and role in immune surveillance.Immunol Rev. 2005 Oct;207:166-83. doi: 10.1111/j.0105-2896.2005.00301.x. Immunol Rev. 2005. PMID: 16181335 Review.
-
The cross-priming pathway: a portrait of an intricate immune system.Scand J Immunol. 2007 Apr;65(4):311-9. doi: 10.1111/j.1365-3083.2007.01909.x. Scand J Immunol. 2007. PMID: 17386021 Review.
-
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.Immunol Rev. 2005 Oct;207:145-57. doi: 10.1111/j.0105-2896.2005.00316.x. Immunol Rev. 2005. PMID: 16181333 Review.
-
[Molecular basis for detection of infectious agents].Schweiz Med Wochenschr. 1996 Feb 17;126(7):246-54. Schweiz Med Wochenschr. 1996. PMID: 8720322 French.
-
Heat shock proteins in antigen trafficking--implications on antigen presentation to T cells.Int J Hyperthermia. 2009 Dec;25(8):617-25. doi: 10.3109/02656730902902183. Int J Hyperthermia. 2009. PMID: 19551545 Review.
Cited by
-
Harnessing human plasmacytoid dendritic cells as professional APCs.Cancer Immunol Immunother. 2012 Aug;61(8):1279-88. doi: 10.1007/s00262-012-1210-z. Cancer Immunol Immunother. 2012. PMID: 22294456 Free PMC article. Review.
-
Autophagy in toxicology: self-consumption in times of stress and plenty.J Appl Toxicol. 2012 Jul;32(7):465-79. doi: 10.1002/jat.1787. Epub 2012 Feb 15. J Appl Toxicol. 2012. PMID: 22334383 Free PMC article. Review.
-
Controlling influenza by cytotoxic T-cells: calling for help from destroyers.J Biomed Biotechnol. 2010;2010:863985. doi: 10.1155/2010/863985. Epub 2010 May 24. J Biomed Biotechnol. 2010. PMID: 20508820 Free PMC article.
-
Role of CD8(+)T cells in the host response to Chlamydia.Microbes Infect. 2008 Nov-Dec;10(14-15):1420-30. doi: 10.1016/j.micinf.2008.08.006. Epub 2008 Aug 26. Microbes Infect. 2008. PMID: 18790073 Free PMC article. Review.
-
Spotlight on TAP and its vital role in antigen presentation and cross-presentation.Mol Immunol. 2022 Feb;142:105-119. doi: 10.1016/j.molimm.2021.12.013. Epub 2021 Dec 29. Mol Immunol. 2022. PMID: 34973498 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
