Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection
- PMID: 16323143
- DOI: 10.1086/498578
Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection
Abstract
To determine mechanisms of neonatal parasite antigen (Ag)-specific immune suppression associated with placental Plasmodium falciparum infection, we isolated cord blood mononuclear cells (CBMCs) from Gabonese neonates born to mothers with differing histories of P. falciparum infection and performed ex vivo and in vitro studies to evaluate immune regulatory activity. We found increased ex vivo percentages of CD4(+)CD25(hi) and CD4(+)CD25(+)CTLA-4(+) cells and increased interleukin (IL)-10 responses to parasite Ag in vitro in CBMCs from neonates born to mothers with placental P. falciparum infection at delivery. Depleting CBMCs of CD4(+)CD25(+) cells before cell culture led to the abrogation of parasite Ag-specific IL-10 responses, to enhanced interferon- gamma responses, and to enhanced expression of CD25 on CD8(+) T cells and of major histocompatibility complex class I and II on monocytes. These data demonstrate that parasite Ag-specific CD4(+) regulatory cells are generated in utero as a consequence of placental P. falciparum infection.
Similar articles
-
IL-12 producing monocytes and IFN-gamma and TNF-alpha producing T-lymphocytes are increased in placentas infected by Plasmodium falciparum.J Reprod Immunol. 2007 Jun;74(1-2):152-62. doi: 10.1016/j.jri.2006.10.001. Epub 2006 Dec 27. J Reprod Immunol. 2007. PMID: 17194481
-
IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria.J Immunol. 2005 Feb 1;174(3):1738-45. doi: 10.4049/jimmunol.174.3.1738. J Immunol. 2005. PMID: 15661939
-
Activation status of cord blood gamma delta T cells reflects in utero exposure to Plasmodium falciparum antigen.J Infect Dis. 2005 May 15;191(10):1612-22. doi: 10.1086/429336. Epub 2005 Apr 7. J Infect Dis. 2005. PMID: 15838787
-
Placental Plasmodium falciparum infection: causes and consequences of in utero sensitization to parasite antigens.Mol Biochem Parasitol. 2007 Jan;151(1):1-8. doi: 10.1016/j.molbiopara.2006.10.001. Epub 2006 Oct 19. Mol Biochem Parasitol. 2007. PMID: 17081634 Review.
-
Malaria blood-stage infection and its control by the immune system.Folia Biol (Praha). 2000;46(6):210-8. Folia Biol (Praha). 2000. PMID: 11140853 Review.
Cited by
-
Neonatal and maternal immunological responses to conserved epitopes within the DBL-gamma3 chondroitin sulfate A-binding domain of Plasmodium falciparum erythrocyte membrane protein 1.Infect Immun. 2005 Dec;73(12):7988-95. doi: 10.1128/IAI.73.12.7988-7995.2005. Infect Immun. 2005. PMID: 16299291 Free PMC article.
-
High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection.Malar J. 2018 May 10;17(1):177. doi: 10.1186/s12936-018-2317-2. Malar J. 2018. PMID: 29743113 Free PMC article.
-
Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy.Cell Immunol. 2021 Jan;359:104244. doi: 10.1016/j.cellimm.2020.104244. Epub 2020 Nov 13. Cell Immunol. 2021. PMID: 33248366 Free PMC article.
-
Beyond Passive Immunity: Is There Priming of the Fetal Immune System Following Vaccination in Pregnancy and What Are the Potential Clinical Implications?Front Immunol. 2018 Jul 16;9:1548. doi: 10.3389/fimmu.2018.01548. eCollection 2018. Front Immunol. 2018. PMID: 30061881 Free PMC article. Review.
-
Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0-2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort.J Trop Med. 2018 Jul 30;2018:6847498. doi: 10.1155/2018/6847498. eCollection 2018. J Trop Med. 2018. PMID: 30154871 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials
