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. 2006 Jan 6;311(5757):83-7.
doi: 10.1126/science.1117729. Epub 2005 Dec 1.

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells

Darin K Fogg  1 , Claire Sibon, Chaouki Miled, Steffen Jung, Pierre Aucouturier, Dan R Littman, Ana Cumano, Frederic Geissmann
Affiliations

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells

Darin K Fogg et al. Science. .

Erratum in

  • Science. 2006 Mar 3;311(5765):1242

Abstract

Macrophages and dendritic cells (DCs) are crucial for immune and inflammatory responses and belong to a network of cells that has been termed the mononuclear phagocyte system (MPS). However, the origin and lineage of these cells remain poorly understood. Here, we describe the isolation and clonal analysis of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo. It was also possible to recapitulate this differentiation in vitro by using treatment with the cytokines macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS.

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