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Comparative Study
. 2005 Dec 1;96(11):1506-11.
doi: 10.1016/j.amjcard.2005.07.059. Epub 2005 Oct 11.

Relation of low socioeconomic status to C-reactive protein in patients with coronary heart disease (from the heart and soul study)

Lindsey A Lubbock  1 , Anne Goh, Sadia Ali, James Ritchie, Mary A Whooley
Affiliations
Comparative Study

Relation of low socioeconomic status to C-reactive protein in patients with coronary heart disease (from the heart and soul study)

Lindsey A Lubbock et al. Am J Cardiol. .

Abstract

Low socioeconomic status (SES) is associated with poor health outcomes in patients who have coronary heart disease (CHD). Inflammation is a potential mechanism by which low SES may lead to adverse cardiovascular outcomes, but it is not known whether low SES is associated with inflammation in patients who have CHD. We measured high-sensitivity C-reactive protein (CRP) levels in a cross-sectional study of 985 adults who had CHD. Income and education were determined by self-report. We used ordinal logistic regression to examine the association of income and education with CRP. Of the 985 participants, 390 had high CRP levels (>3 mg/dl). The proportion of participants who had high CRP levels ranged from 30% (103 of 340) in those who had a college degree to 51% (65 of 127) in those who had less than a high school degree (p<0.0001). The proportion of subjects who had a high CRP level ranged from 28% (52 of 183) in those who had annual income>or=$50,000 to 42% (199 of 974) in those who had an annual income<$20,000 (p<0.001). After adjustment for traditional cardiovascular risk factors and other potential confounding variables, lower income and education remained associated with higher CRP levels. In conclusion, low SES is associated with high CRP levels in patients who have CHD. This observation raises the possibility that inflammation may contribute to the adverse cardiovascular outcomes associated with low SES.

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Figure 1
Figure 1
Proportion of participants who had high CRP levels according to income and education level (p for trend <0.01).
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References

    1. Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA. 2003;290:215–221. - PMC - PubMed
    1. Beattie MS, Shlipak MG, Liu H, Browner WS, Schiller NB, Whooley MA. C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study. Circulation. 2003;107:245–250. - PMC - PubMed
    1. Owen N, Poulton T, Hay FC, Mohamed-Ali V, Steptoe A. Socioeconomic status, CRP, immune factors, and responses to acute mental stress. Brain Behav Immun. 2003;17:286–295. - PubMed
    1. Ridker PM. Inflammation in atherothrombosis: how to use high-sensitivity C-reactive protein (hsCRP) in clinical practice. Am Heart Hosp J. 2004;2:4–9. - PubMed
    1. Blouin AG, Perez EL, Blouin JH. Computerized administration of the Diagnostic Interview Schedule. Psychiatry Res. 1988;23:335–344. - PubMed

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