Reporting clinical trial results to inform providers, payers, and consumers
- PMID: 16284031
- DOI: 10.1377/hlthaff.24.6.1571
Reporting clinical trial results to inform providers, payers, and consumers
Abstract
Results of randomized clinical trials are the preferred "evidence" for establishing the benefits and safety of medical treatments. We present evidence suggesting that the conventional approach to reporting clinical trials has fundamental flaws that can result in overlooking identifiable subgroups harmed by a treatment while underestimating benefits to others. A risk-stratified approach can dramatically reduce the chances of such errors. Since professional and economic incentives reward advocating treatments for as broad a patient population as possible, we suggest that payers and regulatory bodies might need to act to motivate prompt, routine adoption of risk-stratified assessments of medical treatments' safety and benefits.
Similar articles
-
[Controlled randomized clinical trials].Bull Acad Natl Med. 2007 Apr-May;191(4-5):739-56; discussion 756-8. Bull Acad Natl Med. 2007. PMID: 18225427 French.
-
Information technology and medical missteps: evidence from a randomized trial.J Health Econ. 2008 May;27(3):585-602. doi: 10.1016/j.jhealeco.2007.10.008. Epub 2007 Dec 4. J Health Econ. 2008. PMID: 18199511
-
Path to safety: benefits of the 2005 Patient Safety and Quality Improvement Act.Healthc Financ Manage. 2006 Jun;60(6):84-8. Healthc Financ Manage. 2006. PMID: 16773992
-
Multimedia educational aids for improving consumer knowledge about illness management and treatment decisions: a review of randomized controlled trials.J Psychiatr Res. 2008 Jan;42(1):1-21. doi: 10.1016/j.jpsychires.2006.10.004. Epub 2007 Feb 1. J Psychiatr Res. 2008. PMID: 17275026 Review.
-
A critical approach to evidence provided through clinical trials.Nurs Times. 2006 Sep 5-11;102(36):36-8. Nurs Times. 2006. PMID: 16986593 Review.
Cited by
-
Personalized medicine and proper dosage: Over- and undertreatment of chronic diseases endanger patients' health and strain public health systems.EMBO Rep. 2018 Apr;19(4):e45957. doi: 10.15252/embr.201845957. Epub 2018 Feb 27. EMBO Rep. 2018. PMID: 29487086 Free PMC article.
-
Impact of including or excluding both-armed zero-event studies on using standard meta-analysis methods for rare event outcome: a simulation study.BMJ Open. 2016 Aug 16;6(8):e010983. doi: 10.1136/bmjopen-2015-010983. BMJ Open. 2016. PMID: 27531725 Free PMC article.
-
Clinical Trials in Veterinary Medicine: A New Era Brings New Challenges.J Vet Intern Med. 2017 Jul;31(4):970-978. doi: 10.1111/jvim.14744. Epub 2017 May 30. J Vet Intern Med. 2017. PMID: 28557000 Free PMC article.
-
Effect of Medicaid Policy Changes on Medication Adherence: Differences by Baseline Adherence.J Manag Care Spec Pharm. 2017 Mar;23(3):337-345. doi: 10.18553/jmcp.2017.23.3.337. J Manag Care Spec Pharm. 2017. PMID: 28230447 Free PMC article.
-
The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research.Intensive Care Med. 2008 Jun;34(6):1002-11. doi: 10.1007/s00134-008-1062-3. Epub 2008 Mar 19. Intensive Care Med. 2008. PMID: 18350271
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
