Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol
- PMID: 1628156
- PMCID: PMC1908433
- DOI: 10.1111/j.1476-5381.1992.tb09042.x
Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol
Abstract
1. The effects of the typical and typical neuroleptic agents clozapine (CLZ) (2.5-20 mg kg-1, i.p.) and haloperidol (Hal) (0.05-1.0 mg kg-1), were compared on dopamine release and metabolism in the rat prefrontal cortex (PFC), nucleus accumbens (ACC) and striatum (ST). Dopamine release was estimated by measuring the steady-state concentration of 3-methoxytyramine (3-MT) and the level of 3-MT 10 min after pargyline (3-MT accumulation); dopamine metabolism was evaluated from the steady-state concentrations of its acidic metabolites. 2. Both drugs increased 3-MT accumulation in the PFC in a dose-dependent manner. In contrast to Hal, CLZ failed to increase 3-MT accumulation in the ACC or ST. The ST was the region most sensitive to Hal in terms of 3-MT accumulation and, by inference, dopamine release. 3. Both CLZ and Hal dose-dependently elevated the concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in all 3 brain regions studied. The ACC appears to be the region most sensitive to these drugs in terms of changes in the levels of HVA. 4. The result of the present investigations suggest measurements of 3-MT production in the 3 brain regions analysed might be a useful and simple pharmacological tool in the search for atypical neuroleptic drugs with a selectivity of action for the cortical systems.
Similar articles
-
3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model.J Neurochem. 1994 Sep;63(3):972-9. doi: 10.1046/j.1471-4159.1994.63030972.x. J Neurochem. 1994. PMID: 7914228
-
Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats.Br J Pharmacol. 1990 Aug;100(4):774-8. doi: 10.1111/j.1476-5381.1990.tb14091.x. Br J Pharmacol. 1990. PMID: 2207499 Free PMC article.
-
Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.J Pharmacol Exp Ther. 1994 Mar;268(3):1452-61. J Pharmacol Exp Ther. 1994. PMID: 8138957
-
Stress and the mesocorticolimbic dopamine systems.Ann N Y Acad Sci. 1988;537:138-47. doi: 10.1111/j.1749-6632.1988.tb42102.x. Ann N Y Acad Sci. 1988. PMID: 3059920 Review. No abstract available.
-
Effects of chronic neuroleptic treatment on dopamine release: insights from studies using 3-methoxytyramine.J Neural Transm (Vienna). 1996;103(7):777-805. doi: 10.1007/BF01273358. J Neural Transm (Vienna). 1996. PMID: 8872864 Review.
Cited by
-
Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine.Biol Psychiatry. 2007 Mar 1;61(5):679-87. doi: 10.1016/j.biopsych.2006.05.016. Epub 2006 Oct 13. Biol Psychiatry. 2007. PMID: 17046721 Free PMC article.
-
Different effects of scopolamine on extracellular acetylcholine levels in neostriatum and nucleus accumbens measured in vivo: possible interaction with aversive stimulation.J Neural Transm Gen Sect. 1994;97(1):13-25. doi: 10.1007/BF01277959. J Neural Transm Gen Sect. 1994. PMID: 7888146
-
The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels.Front Neurosci. 2019 Apr 3;13:187. doi: 10.3389/fnins.2019.00187. eCollection 2019. Front Neurosci. 2019. PMID: 31001069 Free PMC article.
-
Involvement of different types of dopamine receptors in the formation of latent inhibition of a conditioned passive avoidance reaction in rats.Neurosci Behav Physiol. 2010 Jun;40(5):483-7. doi: 10.1007/s11055-010-9285-5. Epub 2010 May 21. Neurosci Behav Physiol. 2010. PMID: 20490693
-
FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia.Psychopharmacology (Berl). 2004 Aug;175(1):7-17. doi: 10.1007/s00213-004-1782-1. Epub 2004 Mar 6. Psychopharmacology (Berl). 2004. PMID: 15007532
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous