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Clinical Trial
. 2005 Nov;11(11):1230-7.
doi: 10.1038/nm1310. Epub 2005 Oct 16.

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

Aaron P Rapoport  1 , Edward A Stadtmauer, Nicole Aqui, Ashraf Badros, Julio Cotte, Lisa Chrisley, Elizabeth Veloso, Zhaohui Zheng, Sandra Westphal, Rebecca Mair, Nina Chi, Bashi Ratterree, Mary Francis Pochran, Sabrina Natt, Joanne Hinkle, Cheryl Sickles, Ambika Sohal, Kathleen Ruehle, Christian Lynch, Lei Zhang, David L Porter, Selina Luger, Chuanfa Guo, Hong-Bin Fang, William Blackwelder, Kim Hankey, Dean Mann, Robert Edelman, Carl Frasch, Bruce L Levine, Alan Cross, Carl H June
Affiliations
Clinical Trial

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

Aaron P Rapoport et al. Nat Med. 2005 Nov.

Abstract

Immunodeficiency is a barrier to successful vaccination in individuals with cancer and chronic infection. We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. Combination immunotherapy consisting of a single early post-transplant infusion of in vivo vaccine-primed and ex vivo costimulated autologous T cells followed by post-transplant booster immunizations improved the severe immunodeficiency associated with high-dose chemotherapy and led to the induction of clinically relevant immunity in adults within a month after transplantation. Immune assays showed accelerated restoration of CD4 T-cell numbers and function. Early T-cell infusions also resulted in significantly improved T-cell proliferation in response to antigens that were not contained in the vaccine, as assessed by responses to staphylococcal enterotoxin B and cytomegalovirus antigens (P < 0.05). In the setting of lymphopenia, combined vaccine therapy and adoptive T-cell transfer fosters the development of enhanced memory T-cell responses.

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