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Review
. 2006 Feb 13;24(7):863-71.
doi: 10.1016/j.vaccine.2005.08.102. Epub 2005 Sep 12.

Obstacles and advances in SARS vaccine development

Deborah R Taylor  1
Affiliations
Review

Obstacles and advances in SARS vaccine development

Deborah R Taylor. Vaccine. .

Abstract

The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.

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Figures

Fig. 1
Fig. 1
Diagram of the SARS coronavirus structure. The outer virion proteins are marked by the spike proteins that form the corona-like projections. The envelope and membrane glycoproteins are embedded in a lipid bilayer obtained from host-cell membranes. The viral RNA is coated with the nucleocapsid protein .
Fig. 2
Fig. 2
Genome organization of SARS-CoV. Coronaviruses are among the largest RNA viruses. The full-length positive sense SARS CoV is approximately 30 kb long. Nonstructural genes are encoded by ORFs 1a and 1b in the 5′ end of the virus. The structural genes (spike, envelope, membrane, and nucleocapsid) are located in the 3′ end, which includes as many as eight genes of unknown function .
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