Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
- PMID: 16163709
- DOI: 10.1002/bies.20290
Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
Abstract
Understanding how traits are integrated at the organismal level remains a fundamental problem at the interface of developmental and evolutionary biology. Hormones, regulatory signaling molecules that coordinate multiple developmental and physiological processes, are major determinants underlying phenotypic integration. The probably best example for this is the lipid-like juvenile hormone (JH) in insects. Here we review the manifold effects of JH, the most versatile animal hormone, with an emphasis on the fruit fly Drosophila melanogaster, an organism amenable to both genetics and endocrinology. JH affects a remarkable number of processes and traits in Drosophila development and life history, including metamorphosis, behavior, reproduction, diapause, stress resistance and aging. While many molecular details underlying JH signaling remain unknown, we argue that studying "hormonal pleiotropy" offers intriguing insights into phenotypic integration and the mechanisms underlying life history evolution. In particular, we illustrate the role of JH as a key mediator of life history trade-offs.
(c) 2005 Wiley Periodicals, Inc.
Similar articles
-
Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster.Evolution. 2007 Aug;61(8):1980-91. doi: 10.1111/j.1558-5646.2007.00151.x. Evolution. 2007. PMID: 17683439
-
How does juvenile hormone control insect metamorphosis and reproduction?Gen Comp Endocrinol. 2012 Dec 1;179(3):477-84. doi: 10.1016/j.ygcen.2012.06.001. Epub 2012 Jun 20. Gen Comp Endocrinol. 2012. PMID: 22728566
-
Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster.Gen Comp Endocrinol. 2005 Jul;142(3):347-56. doi: 10.1016/j.ygcen.2005.02.009. Epub 2005 Mar 17. Gen Comp Endocrinol. 2005. PMID: 15935161
-
Hormone signaling in evolution and development: a non-model system approach.Bioessays. 2005 Jan;27(1):64-75. doi: 10.1002/bies.20136. Bioessays. 2005. PMID: 15612033 Review.
-
Ecdysone signaling cascade and regulation of Drosophila metamorphosis.Arch Insect Biochem Physiol. 1996;33(3-4):231-44. doi: 10.1002/(SICI)1520-6327(1996)33:3/4<231::AID-ARCH5>3.0.CO;2-V. Arch Insect Biochem Physiol. 1996. PMID: 8913033 Review.
Cited by
-
Developmental regulation of ecdysone receptor (EcR) and EcR-controlled gene expression during pharate-adult development of honeybees (Apis mellifera).Front Genet. 2014 Dec 22;5:445. doi: 10.3389/fgene.2014.00445. eCollection 2014. Front Genet. 2014. PMID: 25566327 Free PMC article.
-
bHLH-PAS heterodimer of methoprene-tolerant and Cycle mediates circadian expression of juvenile hormone-induced mosquito genes.Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16576-81. doi: 10.1073/pnas.1214209109. Epub 2012 Sep 24. Proc Natl Acad Sci U S A. 2012. PMID: 23012454 Free PMC article.
-
Unraveling the Molecular Mechanism of Immunosenescence in Drosophila.Int J Mol Sci. 2018 Aug 21;19(9):2472. doi: 10.3390/ijms19092472. Int J Mol Sci. 2018. PMID: 30134574 Free PMC article. Review.
-
Physiological Maturation Lags Behind Behavioral Maturation in Newly Eclosed Drosophila melanogaster Males.Yale J Biol Med. 2018 Dec 21;91(4):399-408. eCollection 2018 Dec. Yale J Biol Med. 2018. PMID: 30588207 Free PMC article.
-
Individual variation and the challenge hypothesis.Horm Behav. 2020 Jul;123:104549. doi: 10.1016/j.yhbeh.2019.06.013. Epub 2019 Jul 20. Horm Behav. 2020. PMID: 31247185 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
