Systems biology in the cell nucleus
- PMID: 16155251
- DOI: 10.1242/jcs.02596
Systems biology in the cell nucleus
Abstract
The mammalian nucleus is arguably the most complex cellular organelle. It houses the vast majority of an organism's genetic material and is the site of all major genome regulatory processes. Reductionist approaches have been spectacularly successful at dissecting at the molecular level many of the key processes that occur within the nucleus, particularly gene expression. At the same time, the limitations of analyzing single nuclear processes in spatial and temporal isolation and the validity of generalizing observations of single gene loci are becoming evident. The next level of understanding of genome function is to integrate our knowledge of their sequences and the molecular mechanisms involved in nuclear processes with our insights into the spatial and temporal organization of the nucleus and to elucidate the interplay between protein and gene networks in regulatory circuits. To do so, catalogues of genomes and proteomes as well as a precise understanding of the behavior of molecules in living cells are required. Converging technological developments in genomics, proteomics, dynamics and computation are now leading towards such an integrated biological understanding of genome biology and nuclear function.
Similar articles
-
Genomes, proteomes, and dynamic networks in the cell nucleus.Histochem Cell Biol. 2002 Aug;118(2):105-16. doi: 10.1007/s00418-002-0446-7. Epub 2002 Jun 29. Histochem Cell Biol. 2002. PMID: 12189514
-
Concepts in nuclear architecture.Bioessays. 2005 May;27(5):477-87. doi: 10.1002/bies.20226. Bioessays. 2005. PMID: 15832379 Review.
-
Beyond the sequence: cellular organization of genome function.Cell. 2007 Feb 23;128(4):787-800. doi: 10.1016/j.cell.2007.01.028. Cell. 2007. PMID: 17320514 Review.
-
Trends in biomedical engineering: focus on Genomics and Proteomics.J Appl Biomater Biomech. 2011 May-Aug;9(2):98-108. doi: 10.5301/JABB.2011.8564. J Appl Biomater Biomech. 2011. PMID: 22065387 Review.
-
Recent advances in proteomics: towards the human proteome.Biomed Chromatogr. 2014 Jun;28(6):848-57. doi: 10.1002/bmc.3157. Biomed Chromatogr. 2014. PMID: 24861753 Review.
Cited by
-
The Effect of Nucleus Size on the Cell Dose in Targeted Radionuclide Therapy - A Monte Carlo Study.J Med Signals Sens. 2020 Apr 25;10(2):113-118. doi: 10.4103/jmss.JMSS_21_19. eCollection 2020 Apr-Jun. J Med Signals Sens. 2020. PMID: 32676447 Free PMC article.
-
Arabidopsis chromatin-associated HMGA and HMGB use different nuclear targeting signals and display highly dynamic localization within the nucleus.Plant Cell. 2006 Nov;18(11):2904-18. doi: 10.1105/tpc.106.047274. Epub 2006 Nov 17. Plant Cell. 2006. PMID: 17114349 Free PMC article.
-
Systems Cytogenomics: Are We Ready Yet?Curr Genomics. 2021 Feb;22(2):75-78. doi: 10.2174/1389202922666210219112419. Curr Genomics. 2021. PMID: 34220294 Free PMC article.
-
Intranuclear binding kinetics and mobility of single native U1 snRNP particles in living cells.Mol Biol Cell. 2006 Dec;17(12):5017-27. doi: 10.1091/mbc.e06-06-0559. Epub 2006 Sep 20. Mol Biol Cell. 2006. PMID: 16987963 Free PMC article.
-
Sorting the nuclear proteome.Bioinformatics. 2011 Jul 1;27(13):i7-14. doi: 10.1093/bioinformatics/btr217. Bioinformatics. 2011. PMID: 21685104 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
