Myosin domain evolution and the primary divergence of eukaryotes
- PMID: 16121172
- DOI: 10.1038/nature03949
Myosin domain evolution and the primary divergence of eukaryotes
Abstract
Eukaryotic cells have two contrasting cytoskeletal and ciliary organizations. The simplest involves a single cilium-bearing centriole, nucleating a cone of individual microtubules (probably ancestral for unikonts: animals, fungi, Choanozoa and Amoebozoa). In contrast, bikonts (plants, chromists and all other protozoa) were ancestrally biciliate with a younger anterior cilium, converted every cell cycle into a dissimilar posterior cilium and multiple ciliary roots of microtubule bands. Here we show by comparative genomic analysis that this fundamental cellular dichotomy also involves different myosin molecular motors. We found 37 different protein domain combinations, often lineage-specific, and many previously unidentified. The sequence phylogeny and taxonomic distribution of myosin domain combinations identified five innovations that strongly support unikont monophyly and the primary bikont/unikont bifurcation. We conclude that the eukaryotic cenancestor (last common ancestor) had a cilium, mitochondria, pseudopodia, and myosins with three contrasting domain combinations and putative functions.
Comment in
-
Evolution: a treasure trove of motors.Nature. 2005 Aug 25;436(7054):1097-9. doi: 10.1038/4361097a. Nature. 2005. PMID: 16121164 No abstract available.
Similar articles
-
Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolution.J Mol Evol. 2003 May;56(5):540-63. doi: 10.1007/s00239-002-2424-z. J Mol Evol. 2003. PMID: 12698292
-
The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.Int J Syst Evol Microbiol. 2002 Mar;52(Pt 2):297-354. doi: 10.1099/00207713-52-2-297. Int J Syst Evol Microbiol. 2002. PMID: 11931142 Review.
-
Evolution: a treasure trove of motors.Nature. 2005 Aug 25;436(7054):1097-9. doi: 10.1038/4361097a. Nature. 2005. PMID: 16121164 No abstract available.
-
Molecular phylogeny of centrohelid heliozoa, a novel lineage of bikont eukaryotes that arose by ciliary loss.J Mol Evol. 2003 Apr;56(4):387-96. doi: 10.1007/s00239-002-2409-y. J Mol Evol. 2003. PMID: 12664159
-
Megaphylogeny, cell body plans, adaptive zones: causes and timing of eukaryote basal radiations.J Eukaryot Microbiol. 2009 Jan-Feb;56(1):26-33. doi: 10.1111/j.1550-7408.2008.00373.x. J Eukaryot Microbiol. 2009. PMID: 19340985 Review.
Cited by
-
Aberrant overexpression of myosin 1b in glioblastoma promotes angiogenesis via VEGF-myc-myosin 1b-Piezo1 axis.J Biol Chem. 2024 Nov;300(11):107807. doi: 10.1016/j.jbc.2024.107807. Epub 2024 Sep 20. J Biol Chem. 2024. PMID: 39307302 Free PMC article.
-
The revised classification of eukaryotes.J Eukaryot Microbiol. 2012 Sep;59(5):429-93. doi: 10.1111/j.1550-7408.2012.00644.x. J Eukaryot Microbiol. 2012. PMID: 23020233 Free PMC article.
-
Massive expansion of the calpain gene family in unicellular eukaryotes.BMC Evol Biol. 2012 Sep 29;12:193. doi: 10.1186/1471-2148-12-193. BMC Evol Biol. 2012. PMID: 23020305 Free PMC article.
-
Collodictyon--an ancient lineage in the tree of eukaryotes.Mol Biol Evol. 2012 Jun;29(6):1557-68. doi: 10.1093/molbev/mss001. Epub 2012 Jan 6. Mol Biol Evol. 2012. PMID: 22319147 Free PMC article.
-
The origin and diversification of eukaryotes: problems with molecular phylogenetics and molecular clock estimation.Philos Trans R Soc Lond B Biol Sci. 2006 Jun 29;361(1470):1039-54. doi: 10.1098/rstb.2006.1845. Philos Trans R Soc Lond B Biol Sci. 2006. PMID: 16754613 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
