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. 2005 Aug 12;309(5737):1090-2.
doi: 10.1126/science.1113109.

Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

William H Wilson  1 , Declan C Schroeder, Michael J Allen, Matthew T G Holden, Julian Parkhill, Bart G Barrell, Carol Churcher, Nancy Hamlin, Karen Mungall, Halina Norbertczak, Michael A Quail, Claire Price, Ester Rabbinowitsch, Danielle Walker, Marie Craigon, Douglas Roy, Peter Ghazal
Affiliations

Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

William H Wilson et al. Science. .

Abstract

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

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