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. 2006 Mar;43(7):897-914.
doi: 10.1016/j.molimm.2005.06.043. Epub 2005 Aug 9.

A homolog of the human chemokine receptor CXCR1 is expressed in the mouse

Barbara Moepps  1 , Elke Nuesseler, Mike Braun, Peter Gierschik
Affiliations

A homolog of the human chemokine receptor CXCR1 is expressed in the mouse

Barbara Moepps et al. Mol Immunol. 2006 Mar.

Abstract

Two distinct genes are present in the human genome encoding receptors for human interleukin-8 (hCXCL8), referred to as hCXCR1 and hCXCR2. While it seems clear that orthologous genes are present in the genomes of several mammals, the existence of a gene encoding an ortholog of hCXCR1 in the mouse has thus far been controversial. We have isolated a cDNA that is highly similar to the cDNAs of hCXCR1 and hCXCR2, but is clearly distinct from the cDNA encoding mouse CXCR2 (mCXCR2). The encoded protein, designated mouse CXCR1-like (mCXCR1-like), shares 64, 57, 57, and 89% identical amino acids with hCXCR1, hCXCR2, mCXCR2, and rCXCR1-like, respectively. The gene encoding mCXCR1-like was mapped to mouse chromosome 1 and its genomic organization was determined to be very similar to the organization of the gene encoding hCXCR1. Like hCXCR1, mCXCR1-like was found to be expressed at the mRNA level in neutrophils. In addition, mRNA encoding mCXCR1-like was detected in liver, kidney, and spleen. In spleen, mCXCR1-like transcripts were predominantly found in CD4+ T cells. In liver, mCXCR1-like transcripts were identified in residual CD3+ T cells and macrophages, suggesting that mCXCR1-like may regulate inflammatory and immunological processes in the liver. When expressed as a recombinant protein, mCXCR1-like was not activated by a large panel of known CXC chemokines of human and murine origin. These findings suggest that a homolog or ortholog of hCXCR1 is expressed in the mouse to be activated by a hitherto unknown CXC chemokine of the mouse.

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