Review
doi: 10.4161/cc.4.9.1979.
Epub 2005 Sep 28.
Ran-GTP regulates kinetochore attachment in somatic cells
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- PMID: 16082212
- DOI: 10.4161/cc.4.9.1979
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Review
Ran-GTP regulates kinetochore attachment in somatic cells
Cell Cycle.
2005 Sep.
Abstract
The Ran GTPase controls multiple mitotic processes in Xenopus egg extracts, including mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. We have analyzed Ran's role in somatic cells. We uncovered a novel mitotic role of Ran-GTP, involving the Crm1 nuclear export receptor. This pathway is an important mode of Ran-GTP function during mitosis in mammalian somatic cells, which mediates the recruitment of the RanGAP1/RanBP2 complex to kinetochores and maintains the microtubule-based fibers connecting kinetochores to spindle poles (k-fibers). Here we discuss potential implications of these findings for normal k-fiber assembly.
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