Review
doi: 10.1038/nrm1684.
AAA+ proteins: have engine, will work
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- PMID: 16072036
- DOI: 10.1038/nrm1684
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Review
AAA+ proteins: have engine, will work
Nat Rev Mol Cell Biol.
2005 Jul.
Abstract
The AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.
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