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. 2005 Jul-Aug;30(4):380-4.
doi: 10.1016/j.rapm.2005.04.004.

Scavenging nanoparticles: an emerging treatment for local anesthetic toxicity

Elizabeth M Renehan  1 , F Kayser Enneking, Manoj Varshney, Richard Partch, Donn M Dennis, Timothy E Morey
Affiliations

Scavenging nanoparticles: an emerging treatment for local anesthetic toxicity

Elizabeth M Renehan et al. Reg Anesth Pain Med. 2005 Jul-Aug.
No abstract available

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Figures

Fig. 1
Fig. 1
Nanoscale size comparisons.
Fig. 2
Fig. 2
Extraction of bupivacaine by nanoparticles. Shown is an oil-in-water emulsion-based nanoparticle composed of an oil (yellow core) and 2 surfactants in a normal saline bulk medium. The surfactants incorporated into the nanoparticle are a coblock nonionic polymer composed of ethylene oxide (black threads) and propylene oxide (red threads), as well as the ionic surfactant sodium caprylate (polar purple circles with aliphatic gray tails). The blue circles represent drug molecules, such as bupivacaine, and are shown partitioning from the hydrophilic medium into the nanoparticle’s hydrophobic core. (Redrawn from Varshney et al., J Am Chem Soc 2004;126: 5108–5112. Used by permission.)
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