Fecundability according to male serum inhibin B--a prospective study among first pregnancy planners
- PMID: 16024538
- DOI: 10.1093/humrep/dei141
Fecundability according to male serum inhibin B--a prospective study among first pregnancy planners
Abstract
Background: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability.
Methods: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343).
Results: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B #100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively.
Conclusion: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option.
Similar articles
-
The role of inhibin B in prediction of in vitro fertilization or intracytoplasmic sperm injection cycles' outcome.Saudi Med J. 2007 Jul;28(7):1028-33. Saudi Med J. 2007. PMID: 17603704
-
Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men.J Clin Endocrinol Metab. 1997 Dec;82(12):4059-63. doi: 10.1210/jcem.82.12.4456. J Clin Endocrinol Metab. 1997. PMID: 9398713
-
Seminal plasma inhibin-B level is a useful predictor of the success of conventional testicular sperm extraction in patients with non-obstructive azoospermia.J Obstet Gynaecol Res. 2005 Oct;31(5):384-8. doi: 10.1111/j.1447-0756.2005.00306.x. J Obstet Gynaecol Res. 2005. PMID: 16176504
-
Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy.Hum Reprod Update. 2005 Mar-Apr;11(2):123-35. doi: 10.1093/humupd/dmh057. Epub 2004 Dec 23. Hum Reprod Update. 2005. PMID: 15618291 Review.
-
[Serum inhibin A and inhibin B--new clinical markers].Akush Ginekol (Sofiia). 2004;43(6):27-32. Akush Ginekol (Sofiia). 2004. PMID: 15669650 Review. Bulgarian.
Cited by
-
Sperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular cancer.Br J Cancer. 2012 Nov 20;107(11):1833-9. doi: 10.1038/bjc.2012.471. Br J Cancer. 2012. PMID: 23169336 Free PMC article.
-
Pyrethroid insecticide metabolites are associated with serum hormone levels in adult men.Reprod Toxicol. 2009 Apr;27(2):155-60. doi: 10.1016/j.reprotox.2008.12.012. Epub 2009 Jan 24. Reprod Toxicol. 2009. PMID: 19429394 Free PMC article.
-
Functions of somatic cells for spermatogenesis in stallions.J Anim Sci Technol. 2022 Jul;64(4):654-670. doi: 10.5187/jast.2022.e57. Epub 2022 Jul 31. J Anim Sci Technol. 2022. PMID: 35969700 Free PMC article. Review.
-
Epidemiologic methods for investigating male fecundity.Asian J Androl. 2014 Jan-Feb;16(1):17-22. doi: 10.4103/1008-682X.122198. Asian J Androl. 2014. PMID: 24369129 Free PMC article. Review.
-
Anthropometric Measurements, Serum Reproductive Hormonal Levels and Sexual Development among Boys in the Rural Western Cape, South Africa.Int J Environ Res Public Health. 2016 Nov 29;13(12):1185. doi: 10.3390/ijerph13121185. Int J Environ Res Public Health. 2016. PMID: 27916832 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
