Optical coherence tomography: a pilot study of a new imaging technique for noninvasive examination of cervical tissue
- PMID: 16021063
- DOI: 10.1016/j.ajog.2004.11.054
Optical coherence tomography: a pilot study of a new imaging technique for noninvasive examination of cervical tissue
Abstract
Objective: Optical coherence tomography (OCT) is a novel noninvasive technique that can map subsurface tissue structure with a resolution of 10 to 20 mum. The objective of this study was to determine whether an OCT imaging system could be used clinically in vivo to image and distinguish features of normal and abnormal cervical tissue.
Study design: Cervical OCT images and biopsy specimens were obtained from consenting volunteers. Images were analyzed quantitatively for intensity of backscattered light from the epithelia and for rates of signal decay of signal over the depth of epithelia (slope). Patients were stratified by menopausal status, and parameters were compared in normal and abnormal cervical samples, as diagnosed by routine histopathologic techniques.
Results: Average epithelial intensities were significantly stronger in the abnormal tissue than in the normal tissue of premenopausal women (P<.0024), but were stronger in the normal tissue of postmenopausal women (P<.062). No significant differences in signal decay rate were detected.
Conclusion: OCT images, which contain information about epithelial and stromal structure, can be clinically obtained. Image features of normal and abnormal cervical epithelium differ significantly.
Similar articles
-
Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva.Int J Gynecol Cancer. 2004 May-Jun;14(3):470-4. doi: 10.1111/j.1048-891x.2004.14307.x. Int J Gynecol Cancer. 2004. PMID: 15228420
-
The incidental finding of abnormal cervical histology in postmenopausal patients.Maturitas. 1995 Feb;21(2):115-20. doi: 10.1016/0378-5122(94)00866-6. Maturitas. 1995. PMID: 7752948
-
Validation of an ex vivo human cervical tissue model for optical imaging studies.Lasers Surg Med. 2012 Mar;44(3):245-8. doi: 10.1002/lsm.22001. Epub 2012 Jan 13. Lasers Surg Med. 2012. PMID: 22246999
-
Significance of dysplasia.Clin Obstet Gynecol. 1970 Dec;13(4):873-88. doi: 10.1097/00003081-197012000-00005. Clin Obstet Gynecol. 1970. PMID: 4930556 Review. No abstract available.
-
Cervical intraepithelial neoplasia.J Clin Pathol. 1982 Jan;35(1):1-13. doi: 10.1136/jcp.35.1.1. J Clin Pathol. 1982. PMID: 7037858 Free PMC article. Review.
Cited by
-
Quantitative comparison of contrast and imaging depth of ultrahigh-resolution optical coherence tomography images in 800-1700 nm wavelength region.Biomed Opt Express. 2012 Feb 1;3(2):282-94. doi: 10.1364/BOE.3.000282. Epub 2012 Jan 11. Biomed Opt Express. 2012. PMID: 22312581 Free PMC article.
-
A Current Review of Machine Learning and Deep Learning Models in Oral Cancer Diagnosis: Recent Technologies, Open Challenges, and Future Research Directions.Diagnostics (Basel). 2023 Apr 5;13(7):1353. doi: 10.3390/diagnostics13071353. Diagnostics (Basel). 2023. PMID: 37046571 Free PMC article. Review.
-
Feasibility of clinical detection of cervical dysplasia using angle-resolved low coherence interferometry measurements of depth-resolved nuclear morphology.Int J Cancer. 2017 Mar 15;140(6):1447-1456. doi: 10.1002/ijc.30539. Int J Cancer. 2017. PMID: 27883177 Free PMC article. Clinical Trial.
-
Optical biopsy of epithelial cancers by optical coherence tomography (OCT).Lasers Med Sci. 2014 May;29(3):1297-305. doi: 10.1007/s10103-013-1291-8. Epub 2013 Mar 16. Lasers Med Sci. 2014. PMID: 23504262 Free PMC article.
-
Efficacy of optical coherence tomography in the triage of women with minor abnormal cervical cytology before colposcopy.PLoS One. 2023 Mar 13;18(3):e0282833. doi: 10.1371/journal.pone.0282833. eCollection 2023. PLoS One. 2023. PMID: 36913396 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
