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. 2005 Jul;125(1):61-7.
doi: 10.1111/j.0022-202X.2005.23681.x.

Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study

Luigi Naldi  1 , Liliane Chatenoud, Dennis Linder, Anna Belloni Fortina, Andrea Peserico, Anna Rosa Virgili, Pier Luigi Bruni, Vito Ingordo, Giovanni Lo Scocco, Carmen Solaroli, Donatella Schena, Annalisa Barba, Anna Di Landro, Enrico Pezzarossa, Fabio Arcangeli, Claudia Gianni, Roberto Betti, Paolo Carli, Alessandro Farris, Gian Franco Barabino, Carlo La Vecchia
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Free article

Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study

Luigi Naldi et al. J Invest Dermatol. 2005 Jul.
Free article

Abstract

We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n=560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n=690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR=5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR=1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI >/= 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values >/=115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.

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