Fibulins and cancer: friend or foe?
- PMID: 15961345
- DOI: 10.1016/j.molmed.2005.06.001
Fibulins and cancer: friend or foe?
Abstract
The fibulins are a family of secreted glycoproteins, which are characterised by repeated epidermal-growth-factor-like domains and a unique C-terminal structure. Six distinct fibulin genes, encoding at least nine protein products generated by alternative splicing, have been identified. Considerable evidence is available pointing towards a structural role for fibulins within the extracellular matrix. Fibulins have been shown to modulate cell morphology, growth, adhesion and motility. The dysregulation of certain fibulins occurs in a range of human disorders, including cancer. Indeed, both tumour suppressive and oncogenic activities have been proposed for members of the fibulin family. Herein, we discuss the possible roles of fibulins in cancer, in addition to their diagnostic and therapeutic potential.
Similar articles
-
Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.Exp Biol Med (Maywood). 2008 Feb;233(2):155-62. doi: 10.3181/0706-RM-167. Exp Biol Med (Maywood). 2008. PMID: 18222970
-
Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-β in Physiological and Pathological Conditions.Int J Mol Sci. 2018 Sep 17;19(9):2787. doi: 10.3390/ijms19092787. Int J Mol Sci. 2018. PMID: 30227601 Free PMC article. Review.
-
Fibulins: multiple roles in matrix structures and tissue functions.Cell Mol Life Sci. 2009 Jun;66(11-12):1890-902. doi: 10.1007/s00018-009-8632-6. Cell Mol Life Sci. 2009. PMID: 19189051 Free PMC article. Review.
-
A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization.J Biol Chem. 2007 Apr 20;282(16):11805-16. doi: 10.1074/jbc.M611029200. Epub 2007 Feb 26. J Biol Chem. 2007. PMID: 17324935
-
Fibulins: a versatile family of extracellular matrix proteins.Nat Rev Mol Cell Biol. 2003 Jun;4(6):479-89. doi: 10.1038/nrm1130. Nat Rev Mol Cell Biol. 2003. PMID: 12778127 Review.
Cited by
-
Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment.Oncogene. 2015 Nov 5;34(45):5635-47. doi: 10.1038/onc.2015.13. Epub 2015 Mar 30. Oncogene. 2015. PMID: 25823021 Free PMC article.
-
Cell Derived Matrix Fibulin-1 Associates With Epidermal Growth Factor Receptor to Inhibit Its Activation, Localization and Function in Lung Cancer Calu-1 Cells.Front Cell Dev Biol. 2020 Jul 3;8:522. doi: 10.3389/fcell.2020.00522. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32719793 Free PMC article.
-
Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas.BMC Cancer. 2015 Mar 4;15:91. doi: 10.1186/s12885-015-1100-9. BMC Cancer. 2015. PMID: 25885889 Free PMC article.
-
Loss of fibulin-2 expression is associated with breast cancer progression.Am J Pathol. 2007 May;170(5):1535-45. doi: 10.2353/ajpath.2007.060478. Am J Pathol. 2007. PMID: 17456760 Free PMC article.
-
EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer.Int J Biol Sci. 2019 Aug 8;15(10):2139-2155. doi: 10.7150/ijbs.35541. eCollection 2019. Int J Biol Sci. 2019. PMID: 31592144 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
