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Review
. 2005 Jul;21(7):367-70.
doi: 10.1016/j.tig.2005.05.006.

Sex determination: a tale of two Sox genes

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Review

Sex determination: a tale of two Sox genes

Peter Koopman. Trends Genet. 2005 Jul.

Abstract

Vertebrates use many different strategies to determine sex, but the Sox9 gene is a common thread, probably acting as the pivotal gene that controls the male-determining pathway. It now appears that Sox9 is not alone in this role, and that a closely related gene, Sox8, can partly substitute for Sox9. But is this a clever backup strategy to safeguard male development, or a relic of the past?

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